paeonol/hyperalgesia

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Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia.

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1. Paeonol was tested for its anti-inflammatory and analgesic effects in a rat model of carrageenan-evoked thermal hyperalgesia. The possible mechanisms involved in these effects were also investigated. 2. Pre- and post-treatment with paeonol (30, 50 or 100 mg kg(-1), i.p.) dose-dependently

Inhibiting the LPS-induced enhancement of mEPSC frequency in superficial dorsal horn neurons may serve as an electrophysiological model for alleviating pain.

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Pain is a major primary health care problem. Emerging studies show that inhibition of spinal microglial activation reduces pain. However, the precise mechanisms by which microglial activation contributes to nociceptive synaptic transmission remain unclear. In this study, we measured spontaneous

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