panax notoginseng/edema

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[Effect of panax notoginseng saponins injection on brain edema in intracerebral hemorrhage rats].

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OBJECTIVE To study the effect of panax notoginseng saponins (PNS) in treating hemorrhagic apoplexy at super-early stage in rats. METHODS Rat model of hypertension with cerebral hemorrhage was induced by collagenase method. Sixty rats were randomly divided into 5 groups: the sham operated group,

[Effects of ginseng total saponin on traumatic brain edema of rats].

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OBJECTIVE To observe the effects of ginseng total saponin (GTS) on the water content in the brain tissue, the activity of superoxide dismutase (SOD), the content of malondialdehyde (MDA), the expression levels of tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta), and the

[Similarities and differences between Ginkgo biloba and Panax notoginseng in treatment of ischemic cerebrovascular disease]

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Ginkgo biloba and Panax notoginseng are both herb medicines for cerebrovascular disease, and play an active role in treating ischemic cerebrovascular disease(ICVD). Their mechanisms of action include antioxidant stress, nerve protection, vascular protection. According to the comparative study of

Pseudoginsenoside-F11 improves long-term neurological function and promotes neurogenesis after transient cerebral ischemia in mice.

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Stroke is the leading cause of long-term motor disability and cognitive impairment beside the acute brain injury. Recently, neurogenesis has become an attractive strategy for the chronic recovery of stroke. Our previous study showed that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin,

Anti-inflammatory effects of trilinolein from Panax notoginseng through the suppression of NF-κB and MAPK expression and proinflammatory cytokine expression.

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In this study, we have investigated the anti-inflammatory effects of trilinolein (TL) using a lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) and carrageenan (Carr)-induced mouse paw edema model. When RAW264.7 macrophages were treated with different concentrations of TL together with

[The pharmacokinetics and pharmacodynamics of intranasal preparation of Panax notoginseng Saponins].

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OBJECTIVE To investigate the pharmacokinetic course of intranasal powders of Panax notoginseng Saponins (PNS) in a rat model and its protective effects against cardio-cerebrovascular diseases administrated in the form of its suspension. METHODS After administration, Rgl concentration in the serum

[Protective effects and its mechanism of panaxatriol saponins isolated from Panax notoginseng on cerebral ischemia].

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OBJECTIVE To study the protective effects and its mechanism of Panaxatriol Saponins isolated from Panax notoginseng (PTS) on focal cerebral ischemia in rat brain. METHODS The influences of PTS on cerebral water content and three specific proteins (VEGF, HSP70 and transferrin) related with cerebral

Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway.

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This study is to determine the therapeutic effects of Panax notoginseng saponins (PNSs) on coxsackievirus B3 (CVB3)-induced myocarditis, and whether cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S) pathway is involved. Mouse model of myocarditis was induced by CVB3 infection, and the mice were

[Study on therapeutic window of opportunity for Panax notoginseng saponins following focal cerebral ischemia/reperfusion injury in rats].

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OBJECTIVE To study the therapeutic window of opportunity for Panax notoginseng saponins (Pns) following focal cerebral ischemia/reperfusion injury in rats. METHODS Focal cerebral ischemia (2 h)/reperfusion (24 h) model in male rats was induced by transient occlusion and middle cerebral artery (MCA)

[Effect of Panax notoginseng saponins combined isovolumic haemodilution on the retinal microcirculation of patients with retinal vein occlusion].

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OBJECTIVE To study the effect of Panax notoginseng saponins (PNS) or isovolumic haemodilution (IHD) and combination of PNS with IHD on retinal microcirculation of patients with retinal vein occlusion (RVO). METHODS Seventy three patients with RVO were allocated at random to three groups which were

Neuroprotective effect of Panax notoginseng plysaccharides against focal cerebral ischemia reperfusion injury in rats.

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Our present study was conducted to investigate whether Panax notoginseng plysaccharides (PNPS) exerted a neuroprotective effect against focal cerebral ischemia/reperfusion (I/R) injury in rats. Before mice were subjected to middle cerebral artery occlusion (MCAO) for 2 h and reperfusion for 22 h,

Protective effects of geniposide and ginsenoside Rg1 combination treatment on rats following cerebral ischemia are mediated via microglial microRNA‑155‑5p inhibition.

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Geniposide, an active component of Gardenia, has been reported to protect against cerebral ischemia in animals. Ginsenoside Rg1, a component of Panax notoginseng, is usually administered in combination with Gardenia for the treatment of acute ischemic stroke; however, there are unknown effects of

Effects of four herbal extracts on adjuvant-induced inflammation and hyperalgesia in rats.

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OBJECTIVE To evaluate the effects of four herbal medicine extracts on a rat model of inflammatory hyperalgesia. METHODS Inflammation was induced by injecting complete Freund's adjuvant (CFA) into one hindpaw of each rat. Four herbs that are routinely prescribed in Traditional Chinese Medicine for

Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components.

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BACKGROUND Panax notoginseng (Burk) F.H. Chen (Araliaceae) is a well-known and commonly used traditional Chinese herb for treatment of various diseases, such as hemostasis, edema and odynolysis. OBJECTIVE Our aim was to investigate the mechanisms of anti-hyperglycemic and anti-obese effects of Panax

Efficacy and Safety of Panax notoginseng Saponin Therapy for Acute Intracerebral Hemorrhage, Meta-Analysis, and Mini Review of Potential Mechanisms of Action.

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Intracranial/intracerebral hemorrhage (ICH) is a leading cause of death and disability in people with traumatic brain injury (TBI) and stroke. No proven drug is available for ICH. Panax notoginseng (total saponin extraction, PNS) is one of the most valuable herb medicines for stroke and

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