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pancreatitis/protease
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Test system for the determination of in-vivo active hemostasis proteases or of trypsin or subtilisin in biological fluids and/or the usage thereof to determine the in-vivo activation of hemostasis or to diagnose a pancreatitis
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DESCRIPTION
Test system for the determination of in-vivo active hemostasis proteases or of trypsin or subtilisin in biological fluids and/or the usage thereof to determine the in-vivo activation of hemostasis or to diagnose a pancreatitis.
The present invention relates to a global procedure basing
Serine protease BSSP5
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The present application is the national stage under 35 U.S.C. .sctn.371 of international application PCT/JP99/06473, filed 19 Nov. 1999 which designated the United States, and which application was not published in the English language.
FIELD OF THE INVENTION
The present invention relates to
Test system for the determination of in-vivo active hemostasis proteases in biological fluids and/or the usage thereof to determine the in-vivo activation of hemostasis
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The present invention relates to a global procedure basing on peptide substrates for the determination of in-vivo active hemostasis proteases or of in-vivo active trypsin or of subtilisin in biological fluids, that particularly can be used to determine the in-vivo activation of hemostasis,
Protease variants for pharmaceutical use
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REFERENCE TO A SEQUENCE LISTING
This application contains a Sequence Listing in computer readable form. The computer readable form is incorporated herein by reference.
TECHNICAL FIELD
The present invention relates to a protease having at least 90% identity to amino acids 1-188 of SEQ ID NO: 1, and
Therapeutic application of Kazal-type serine protease inhibitors
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This is a national stage entry of PCT/EP2008/001009, filed Feb. 11, 2008, which claims priority to EP 07002903.8, filed Feb. 12, 2007, all of which are incorporated herein by reference.
The subject of the present invention is, in the most general aspect, the therapeutic application of the Kazal-type
Derivatives, having an inhibitory action against protease and an antiphlogistic action, of the trypsin-kallikrein inhibitor obtained from cattle organs (BPTI), their preparation and their use as medicaments
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The present invention relates to new derivatives of trypsin-kallikrein inhibitor, obtainable from cattle organs, which is called BPTI (basic pancreatic trypsin inhibitor [Kunitz]) in the text which follows, and to processes for the preparation of these derivatives from natural BPTI or from
Azetidin-2-one derivatives as serine protease inhibitors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel 3-guanidinoalkyl-2-azetidinones useful for anti-thrombin and anti-trypsin activity.
2. Description of Related Art
The traditional use of compounds containing beta-lactam structures has been for antibacterial
Azetidin-2-one derivatives as serine protease inhibitors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel 3-guanidinoalkyl-2-azetidinones useful for anti-thrombin and anti-trypsin activity.
2. Description of Related Art
The traditional use of compounds containing beta-lactam structures has been for antibacterial
Azetidin-2-one derivatives as serine protease inhibitors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel 3-guanidinoalkyl-2-azetidinones useful for anti-thrombin and anti-trypsin activity.
2. Description of Related Art
The traditional use of compounds containing beta-lactam structures has been for antibacterial
Azetidin-2-one derivatives as serine protease inhibitors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel 3-guanidinoalkyl-2-azetidinones useful for anti-thrombin and anti-trypsin activity.
2. Description of Related Art
The traditional use of compounds containing beta-lactam structures has been for antibacterial
Azetidin-2-one derivatives as serine protease inhibitors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel 3-guanidinoalkyl-2-azetidinones useful for anti-thrombin and anti-trypsin activity.
2. Description of Related Art
The traditional use of compounds containing beta-lactam structures has been for antibacterial
Phenyl guanidinobenzoate derivatives which have protease inhibitory activity
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel benzoyl esters and acid addition salts thereof which have the inhibitory activities against proteases and are thus useful as a medicine.
2. Description of the Prior Art
It is known that various guanidinobenzoic
Lipase variants for pharmaceutical use
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REFERENCE TO A SEQUENCE LISTING
This application contains a Sequence Listing in computer readable form. The computer readable form is incorporated herein by reference.
TECHNICAL FIELD
The present invention relates to a lipase for use as a medicament, which lipase (a) has at least 50% identity to the
Lipase variants for pharmaceutical use
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REFERENCE TO A SEQUENCE LISTING
This application contains a Sequence Listing in computer readable form. The computer readable form is incorporated herein by reference.
TECHNICAL FIELD
The present invention relates to a lipase for use as a medicament, which lipase (a) has at least 50% identity to the
Lipase variants for pharmaceutical use
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REFERENCE TO A SEQUENCE LISTING
This application contains a Sequence Listing in computer readable form. The computer readable form is incorporated herein by reference.
TECHNICAL FIELD
The present invention relates to a lipase for use as a medicament, which lipase (a) has at least 50% identity to the
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