papaver argemone/breast neoplasms

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Synthesis and biological evaluation of N-substituted noscapine analogues.

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Noscapine is a phthalideisoquinoline alkaloid isolated from the opium poppy Papaver somniferum. It has long been used as an antitussive agent, but has more recently been found to possess microtubule-modulating properties and anticancer activity. Herein we report the synthesis and pharmacological

Noscapine targets EGFRp-Tyr1068 to suppress the proliferation and invasion of MG63 cells.

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Osteosarcoma, the most common primary malignant bone tumor, usually arises in the metaphysis of long bones. Amplification and mutation of the epidermal growth factor receptor (EGFR) gene represent signature genetic abnormalities encountered in osteosarcoma. Noscapine is a benzylisoquinoline alkaloid

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