Dehydroepiandrosterone (DEA), a metabolite of steroid hormone in the urine, differed from papaverine in the mode of inhibitory action on the isolated guinea-pig ileum. Papaverine inhibited both phasic and tonic contractions induced by an agonist, while DEA inhibited the phasic contraction without
BACKGROUND
Limitation of the blood supply to skeletal muscle in chronic heart failure may contribute to the symptoms of fatigue and diminished exercise capacity. The pathophysiology underlying this abnormality is not known. The purpose of this study was to assess the effect of endothelium dependent
Verapamil, a papaverine calcium channel blocker, has been used effectively and safely in the treatment of angina pectoris and auricular arrhythmias, and more recently in the treatment of mania. Many antipsychotic drugs show calcium channel blocking effects similar to verapamil's. A 41 year old male
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