paratuberculosis/hypoxia

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Growth pattern and partial proteome of Mycobacterium avium subsp. paratuberculosis during the stress response to hypoxia and nutrient starvation.

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Mycobacterium avium subsp. paratuberculosis is an important pathogen that causes Johne's disease in animals and has been implicated in Crohn's disease in man yet few data exist on its physiological adaptation in either the host or the environment. In this study, the proteomic responses of the two

Evaluation of the immunogenicity of recombinant stress-associated proteins during Mycobacterium avium subsp. paratuberculosis infection: Implications for pathogenesis and diagnosis.

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The aim of this study was to assess the immunogenicity of recombinant stress-associated proteins of Mycobacterium avium subsp. paratuberculosis in sheep infected with the organism compared to control sheep. Five proteins - MAP2411, ClpP, Ppa, MAP0593c and GreA - which were identified previously in

Partial proteome of Mycobacterium avium subsp. paratuberculosis under oxidative and nitrosative stress.

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The growth pattern and protein expression profiles of sheep (S) and cattle (C) strains of Mycobacterium avium subsp. paratuberculosis (MAP) under oxidative and nitrosative stress were characterised. Oxidative stress was induced using 0.05% (v/v) H(2)O(2) in BACTEC medium, and was lethal for an

Identification and characterization of a spore-like morphotype in chronically starved Mycobacterium avium subsp. paratuberculosis cultures.

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Mycobacteria are able to enter into a state of non-replication or dormancy, which may result in their chronic persistence in soil, aquatic environments, and permissive hosts. Stresses such as nutrient deprivation and hypoxia provide environmental cues to enter a persistent state; however, a clear

A novel Th1-type T-cell immunity-biasing effect of malate dehydrogenase derived from Mycobacterium avium subspecies paratuberculosis via the activation of dendritic cells.

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Mycobacterium avium subspecies paratuberculosis (MAP) is the causative pathogen of Johne's disease in ruminants, characterized by chronic granulomatous enteritis; it also has zoonotic potential and is associated with Crohn's disease in humans. A better understanding of the mycobacterial antigens and

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