parietaria officinalis/protease

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Activation of protease-activated receptor-2 reduces airways inflammation in experimental allergic asthma.

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BACKGROUND Proteinase-activated receptors (PAR)-2 are members of the family of G-protein-coupled receptors activated by proteases. These receptors are widely expressed in several tissues and in virtually all cells involved in rhinitis and asthma. In particular, proteinases activating PAR-2 may

IgE-binding trypsin inhibitors in plant pollen extracts.

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In an attempt to access the possible role of protease-antiprotease mechanisms of non-immune defence in pollinosis, only low levels of trypsin-, kallikrein- or plasmin-like proteinases could be detected in aqueous pollen extracts. In contrast, several pollen species displayed appreciable trypsin

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