pentosane/inflammation

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[Modification of the adjuvans arthritis by carrageenin, compound 48/80, histamine- and serotonin antagonists, non-steroid antiphlogistics as well as protease inhibitors and their possible relations to inflammation mediators].

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1. Injections of carrageenin (1,25 mg/kg i.v.) from the 1st to the 3rd day and then each 2nd or 3rd day inhibited paw swelling in adjuvant arthritis of the rat during the time of treatment. Injections from the 11th to the 15th day were ineffective. The level of plasma kininogen was slightly

[Platelet factor 4, target of anti-heparin antibodies: application to biological diagnosis of heparin-induced thrombopenia].

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Heparin-platelet factor 4 (H-PF4) complexes are the target for heparin-dependent antibodies present in most of heparin-induced thrombocytopenias (HIT). The highest reactivity is obtained with 27 IU of heparin per mg of PF4. Low molecular weight heparin (LMWH) and pentosane polysulphate can also form

Pentosan Polysulfate to control hepcidin expression in vitro and in vivo.

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Hepcidin peptide is crucial in the regulation of systemic iron availability controlling its uptake from the diet and its release from the body storage tissues. Hepcidin dysregulation causes different human disorders ranging from iron overload (e.g. hemochromatosis) to iron deficiency (e.g. anemia).

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