TECHNICAL FIELD OF THE INVENTION
The invention relates to the area of enzyme regulation More particularly, the invention relates to the regulation of human pyroglutamyl peptidase I.
BACKGROUND OF THE INVENTION
The brain enzyme pyroglutamyl peptidase catalyzes the proteolysis of thyrotropin releasing
FIELD OF THE INVENTION
The present invention relates to compounds that act as specific inhibitors of the cysteine protease dipeptidyl peptidase I (DP I). Compounds based on acylated hydroxamates are distinguished by being chemically stable in aqueous solutions, including biological fluids (Bromme
This application is the U.S. National Phase of International Application PCT/CA00/00147, filed Feb. 11, 2000, published in English under PCT Article 21(2), which designated the U.S. PCT/CA00/00147 claims priority to Canadian Patent Application No. 2,260,376, filed Feb. 11, 1999. The entire content
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