The CHCl(3) -soluble fraction obtained from the MeOH extract of Peucedanum japonicum Thunb. inhibited phenylephrine-induced vasoconstriction in isolated rat thoracic aorta. We isolated a vasorelaxing compound, as one of the bioactive components, which was identified as (+)- cis-4'- O-acetyl-3'-
The contractions of isolated rabbit trachea smooth muscles by acetylcholine and potassium chloride were attenuated by petroleum ether extract of Peucedanum praeruptorum pretreatment. The dose-effect curve of acetylcholine was shifted to the right, and the maximal response was diminished. The effect
Praeruptorin C and E isolated from Peucedanum praeruptorum Dunn. decreased the maximum contractile effect of Ca2+ in potassium-depolarized swine coronary strips and shifted the concentration-response curve to the right in a non-parallel manner. The calcium antagonistic activity of praeruptorin C and
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