Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal disorder of the haematopoietic progenitor cells due to a somatic mutation in theX-linked phosphatidylinositol glycan class A gene. The disease is characterized by intravascular haemolytic anaemia, propensity to thromboembolic events
Muscle wasting is a prominent feature of end-stage renal disease and is associated with muscle weakness and poor physical functioning. Potential reasons for muscle wasting include advancing age, sedentary behavior, inflammation, poor nutritional intake, androgen deficiency, oxidative stress,
Skeletal muscle weakness is a common problem among burn patients. An understanding of the changes that occur in the phosphatidyl inositol signal transducing system (sts) in skeletal muscle may identify pharmacological agents that would prove useful in the treatment of these patients. This report
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