TECHNICAL FIELD
The invention relates to the field of treating inflammation in humans and animals. More particularly, the invention concerns a pure preparation of a phospholipase inhibitory protein (PIP) which is effective in controlling inflammation.
BACKGROUND ART
The general physiological
FIELD OF THE INVENTION
The invention concerns the use of monoclonal antibodies against type I phospholipase A.sub.2 for the production of an anti-inflammatory therapeutic agent which is particularly suitable for application in acute pancreatitis.
BACKGROUND OF THE INVENTION
There is neither a causal
FIELD OF THE INVENTION
This invention relates to a series of phosphoinositide-specific phospholipase C (PLC) inhibitors useful in treating or ameliorating an inflammatory disorder. More particularly, the PLC inhibitors are heterocyclyl-substituted anilino compounds useful in treating or ameliorating
TECHNICAL FIELD
The present invention relates to peptide inhibitors of phospholipase A.sub.2 purified from inflammatory sites.
BACKGROUND ART
Phospholipase A.sub.2 is an enzyme which hydrolyzes .beta.-ester bonds in phospholipid to give fatty acids and lysophospho-lipids. Especially, it releases
TECHNICAL FIELD
The invention relates to protein inhibiting phospholipase A.sub.2 which participates in the progress of inflammation, the production process and gene therefor. More particularly, the invention concerns rat or human protein inhibitors of phospholipase A.sub.2 purified from
BACKGROUND OF THE INVENTION
Recent studies with rodent Experimental Autoimmune Encephalitis (EAE) models of Multiple Sclerosis (MS) suggest phospholipase A2 (PLA2) enzymes are involved in the genesis of both the behavioral deficits and the inflammation that characterize this disease (Pinto, et al.,
FIELD OF THE INVENTION
The present invention relates generally to the field of non-steroidal anti-inflammatory agents for inhibition of phospholipase A2 enzymes, and the use of such agents in controlling inflammation.
BACKGROUND OF THE INVENTION
Injury to one part of the body often results in
TECHNICAL FIELD OF THE INVENTION
The present invention relates to the isolation and characterization of a microbially-synthesized compound, its derivatives and pharmaceutically acceptable salts thereof, and processes for enzyme inhibition. More particularly, this invention includes a novel
TECHNICAL FIELD
The invention relates to the field of treating inflammation in humans and animals. More particularly, the invention concerns a pure preparation of a phospholipase inhibitory protein (PIP) which is effective in controlling inflammation.
BACKGROUND ART
The general physiological
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a National Stage of International Application No. PCT/KR2012/001855 filed Mar. 14, 2012, claiming priority based on Korean Patent Application No. 10-2011-24239 filed Mar. 18, 2011 the contents of all of which are incorporated herein by
FIELD OF THE INVENTION
The present invention relates to methods for the use of chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A.sub.2 enzymes (cPLA.sub.2), more particularly including inhibitors of cytosolic phospholipase A.sub.2 alpha
FIELD OF THE INVENTION
The present invention relates to methods for the use of chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A.sub.2 enzymes (cPLA.sub.2), more particularly including inhibitors of cytosolic phospholipase A.sub.2 alpha
BACKGROUND OF THE INVENTION
Phospholipases C (EC 3.1.4.3) are a family of enzymes which hydrolyze the sn-3 phosphodiester bond in membrane phospholipids producing diacylglycerol and a phosphorylated polar head group. Mammalian phospholipase C (PLC) enzymes exhibit specificity for the polar head
The present invention relates to a purified calcium independent cytosolic phospholipase A.sub.2 /B enzymes which are useful for assaying chemical agents for anti-inflammatory activity.
BACKGROUND OF THE INVENTION
The phospholipase A.sub.2 enzymes comprise a widely distributed family of enzymes which
The present invention relates to a purified calcium independent cytosolic phospholipase A.sub.2 /B enzymes which are useful for assaying chemical agents for anti-inflammatory activity.
BACKGROUND OF THE INVENTION
The phospholipase A.sub.2 enzymes comprise a widely distributed family of enzymes which
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