phospholipid/breast neoplasms

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A novel injectable phospholipid gel co-loaded with doxorubicin and bromotetrandrine for resistant breast cancer treatment by intratumoral injection.

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Systemically administered anticancer treatments were greatly limited by extensive side effects mainly due to nonspecific distributions in vivo, and multidrug resistance in various tumors. A phospholipids-based in situ-forming gel platform has been developed for the concurrent delivery of doxorubicin

Validation of repeated self-reported n-3 PUFA intake using serum phospholipid fatty acids as a biomarker in breast cancer patients during treatment.

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BACKGROUND The role of n-3 polyunsaturated fatty acids (PUFAs) in breast cancer is not clear and under debate. To explore this relationship it is important to have proper validated dietary assessment methods for measuring the intake of n-3 PUFAs. The aim of the current study is to validate two

[The erythrocyte functional status and phospholipid composition in breast cancer patients].

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A study of the osmotic resistance of both red blood cells and phospholipids of whole blood and isolated red blood cells showed breast cancer with symptoms of metastasis to involve perverted influence of calcium ions on osmoerythrograms. It is also characterized by similarly high levels of

Risk of secondary lymphedema in breast cancer survivors is related to serum phospholipid fatty acid desaturation.

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Secondary lymphedema is a common irreversible side effect of breast cancer surgery. We investigated if risk of secondary lymphedema in breast cancer survivors was related to changes in serum phospholipid fatty acid composition. Study subjects were voluntarily recruited into the following three

[The effect of chemotherapy on the total unsaturation and composition of plasma phospholipids and erythrocytes in patients with disseminated breast cancer].

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The total unsaturation and composition of blood phospholipids were studied in patients with disseminated breast cancer prior to and after chemotherapy. It was shown that the level of double bonds in blood lipids was quite definitely related to the effect of treatment and may have an independent

Hormone sensitivity is reflected in the phospholipid profiles of breast cancer cell lines.

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We have found that the profiles of total phospholipids in malignant breast cancer cell lines change going from hormone sensitive to highly hormone resistant cells lines. In particular, two phospholipid components that were absent or at very low levels in hormone sensitive MCF7 cells and moderately

Significance of serum fucose, sialic acid, haptoglobine and phospholipids levels in the evolution and treatment of breast cancer.

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Serum fucose, sialic acid, haptoglobine and phospholipids were determined in 167 women with breast cancer stages I--III, 30 with benign lesions of the breast, 42 women in various physiological states of the mammary gland (pregnancy, early childbed and lactation) and compared with 30 healthy women as

Activation of inositol phospholipid signaling and Ca2+ efflux in human breast cancer cells by bombesin.

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Members of the bombesin-related family of peptides (BRPs) are mitogenic for a variety of cell types; however, a role for these peptides has not been previously described in human breast cancer. Early membrane receptor signal transduction mechanisms associated with bombesin action include

Fatty acid composition of phospholipids and neutral lipids and lipid peroxidation in human breast cancer and lipoma tissue.

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Since unsaturated fatty acids have been shown to control cell division experimentally the fatty acid composition in human mammary cancers as compared with the healthy surrounding tissue was studied. Both phospholipid and neutral lipid fractions were extracted for study and further lipid peroxidation

[Phospholipid concentrations and localization of selected phospholipids in erythrocyte membranes of breast tumor patients].

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The phospholipid content within the erythrocyte membrane, its composition and topological distribution was determined in 17 untreated patients with histologically verified breast cancer. The qualitative analysis of phospholipids was performed by one- and two-dimensional TLC. Topological changes of

Phospholipids and fatty acids in breast cancer tissue.

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The fatty acid composition of fractionated phospholipids and neutral lipids was analyzed in human breast cancer tissues and the surrounding, apparently healthy tissue. In the cancer tissues the relative amounts of unsaturated fatty acids were increased in all the phospholipid subclasses analyzed.

Fatty acid compositions of inositol and choline phospholipids of breast tumours and normal breast tissue.

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The fatty acid compositions of the -choline and -inositol phospholipids of breast tumours of women undergoing surgery for treatment of breast disease (malignant n = 12; benign n = 10) and normal breast tissue of women undergoing breast reduction surgery (n = 6) were determined. The fatty acid

Malignant breast tumor phospholipid profiles using (31)P magnetic resonance.

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Biochemical markers improve the classification and staging of breast cancer and may refine management decisions if it can be shown that they correlate with accepted prognostic factors or patient outcome. Using phosphorus-31 magnetic resonance spectroscopy ((31)P MRS), we determined the phospholipid

Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor.

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Two-dimensional MoS2 nanosheet has been extensively explored as a photothermal agent for tumor regression; however, its surface modification remains a great challenge. Herein, as an alternative to surface polyethylene glycol modification (PEGylation), a facile approach based on "thin-film" strategy

A comparison of in vivo and in vitro 31P NMR spectra from human breast tumours: variations in phospholipid metabolism.

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An in vivo 31P NMR spectrum was obtained from each of four human breast tumours. The phosphomonoester and phosphodiester region of each spectrum consisted of a broad peak. Chemical extracts from samples of each of the tumours obtained at resection were examined on a high field strength NMR system.

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