Genetic, specifically monogenic, obesity must be suspected: in cases of early severe obesity, developing in the first months of life; in cases of severely abnormal dietary behavior; in cases of associated endocrine abnormalities or pigmentation disorders; in cases of parental consanguinity.
Many researchers have been indicated that premature hair greying (PHG) may be associated with the multifactorial problem include genetic, trace elements deficiencies and some medical problems such as metabolic disorders. However, the risk factors for premature hair greying are not well
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