Type 2 Diabetes Mellitus

Randomized cros-over intervention of 3 OGTT with no oil, low dose or high dose.

Hydrolyzed pine nut oil

Department of Endocrinology

Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.

Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance, Incretins, Appetite and Tolerability in Healthy Humans.

Area under the curve of Insulin and C-peptide

Visual analog scale - area under the curve

Karina Vejrum Sørensen

MSc, PhD-student

Odense University Hospital

University of Southern Denmark

Subjects complete three oral glucose tolerance tests (OGTT) on different days, with a minimum of one week in between. First visit is a combined screening and baseline OGTT, with no supplementation. At the second and third visit subjects are randomly assigned to either 3 g of hydrolyzed pine nut oil or 6 g of hydrolyzed pine nut oil.

Standard OGTT supplemented with 3 g of non-hydrolyzed pine nut oil

Type2 Diabetes Mellitus

Obesity

Subjects are supplemented with either no oil, hydrolyzed oil or non-hydrolyzed oil in combination with an OGTT

Pine nut oil

FFAR Agonist on Incretins, Insulin, Lipids and Inflammation

Effects of a Naturally Occurring Dual FFAR Agonist on Incretins, Insulin Secretion, Lipids and Inflammation in Obesity and Type 2 Diabetes

Changes in blood after a 4hour OGTT (75 g glucose)

Subjects complete three oral glucose tolerance test (OGTT) on different days, with a minimum of one week in between. First visit is a combined screening and baseline OGTT, with no supplementation. The second and third visit subjects are randomly assigned to either 1 g of non-hydrolyzed pine nut oil or 1 g of hydrolyzed pine nut oil.

pinus sibirica/hyperglycemia

Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.

FFAR Agonist on Incretins, Insulin, Lipids and Inflammation

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