piplartine/breast neoplasms

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Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents.

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Piperlongumine (piplartine, 1) is a small molecule alkaloid that is receiving intense interest due to its antiproliferative and anticancer activities. We investigated the effects of 1 on tubulin and microtubules. Using both an isolated tubulin assay, and a combination of sedimentation and western

High-throughput screen of natural product libraries for hsp90 inhibitors.

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Hsp90 has become the target of intensive investigation, as inhibition of its function has the ability to simultaneously incapacitate proteins that function in pathways that represent the six hallmarks of cancer. While a number of Hsp90 inhibitors have made it into clinical trials, a number of

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