polyamine/neoplasms

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Spermine Measuring Device Evaluation Protocol

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Prostate cancer (PC) is highly prevalent worldwide and is currently the 3rd most commonly diagnosed prostate cancer in Hong Kong male population with more than 2000 new cases diagnosed per year. Depending on the clinical staging and also the patients' condition, different treatments, including

Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

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The term "mucositis" was introduced to describe inflammation of the oral mucosa induced by radiotherapy, chemotherapy and bone marrow transplantation. At present, oral mucositis is considered to be the most serious non-hematological complication of cancer treatment. Numerous predisposing factors

Combination of 68Ga-PSMA PET Data With Magnetic Resonance Spectroscopy Data (MRS) for Evaluating Prostate Cancer

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In recent years a new modality has emerged showing promising accuracy targeting the Prostate Specific Membrane Antigen (PSMA) which is significantly overexpressed in prostate tumor cells. By attaching radioactive isotope 68Ga to PSMA ligands, PET/CT molecular imaging can provide information

To Identify Potential New Urine Markers for the Screening of Prostate Cancer

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Prostate cancer (PC) is highly prevalent worldwide and is the second most commonly diagnosed cancer in men globally and is the 5th leading cause of cancer death in men. 1 In some Asian areas, even n with widely used serum Prostate Specific Antigen (PSA) diagnostic testing, more than 50% men with

Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma

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PRIMARY OBJECTIVES: I. To determine whether administration of eflornithine (DFMO) in combination with dinutuximab, irinotecan hydrochloride (irinotecan) and temozolomide results in an improved response rate compared to dinutuximab, irinotecan and temozolomide in patients with relapsed or refractory

Oral AMXT 1501 Dicaprate in Combination With DFMO

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The objective of this study is to determine the safety and tolerability of oral AMXT 1501 dicaprate (AMXT1501) in combination with DFMO in patients with advanced solid tumors. Secondary objectives include characterization of plasma pharmacokinetics (PK) of AMXT 1501 as well as pharmacodynamic (PD)

Use of Mesenchymal Stem Cells in Inflammatory Bowel Disease

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Chronic inappropriate mucosal immune activation, due to aberrant host interactions with intestinal microbiota, is at the heart of inflammatory bowel disease (IBD) pathogenesis. Currently, there is no cure for IBD and mainstays of therapy are limited to non-cell specific

N2012-01: Phase 1 Study of Difluoromethylornithine (DFMO) and Celecoxib With Cyclophosphamide/Topotecan

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Prevention of Oxaliplatin-induced Neuropathic Pain by a Specific Diet

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This is a prospective, single-center, controlled and interventional study with two parallel groups randomized in single-blind. After obtaining informed consent, all included patients will be randomized, either: - in the group with a polyamines depleted diet : 2-4 cans per day of Polydol® (oral

Urinary Excretion of Acetylamantadine by Normal Healthy Volunteers

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A group of 20 female and 20 male normal healthy volunteers ages 18 to 69 will be recruited from the community by use of a general advertisement placed initially as posters. We will tell the volunteers that we are conducting this study in healthy volunteers to determine how amantadine is eliminated

Spectro-IRM and Evaluation Response to Prostatic Radiotherapy

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Acetylsalicylic Acid and Eflornithine in Treating Patients at High Risk for Colorectal Cancer

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PRIMARY OBJECTIVES: I. The proportion of subjects with an adenoma recurrence at the 1-year follow-up colonoscopy exam. This adenoma recurrence rate for difluoromethylornithine (DFMO) (eflornithine) + aspirin will be compared to double placebo to see if there is improvement in the adenoma recurrence

Curcumin in Treating Patients With Familial Adenomatous Polyposis

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Specific Aims: I. To determine in a randomized, double-blinded, placebo-controlled study the tolerability and effectiveness of curcumin to regress intestinal adenomas by measuring duodenal and colorectal/ileal polyp number, and polyp size in familial adenomatous polyposis patients with intact

Trial of Aspirin and Arginine Restriction in Colorectal Cancer

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Polyamine-free Diet to Prevent Post Surgery Hyperalgesia

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This multicentric, single blind study will enrol 160 women (18-75 years old) operated on tumorectomy and adenectomy (T1, T2, T3, N0, N1, M0) for breast cancer. Patients will be randomly assigned in a 2x2 factorial plan : Group 1 = control (n = 40) ; group 2 = ketamine group administered during and

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