A folk prescription consisting of Alnus hirsuta, Rosa davurica, Acanthopanax senticosus and Panax schinseng has been used in the treatment of diabetes mellitus. The aim of the present investigation was to evaluate the antidiabetic effects of the herb formula extract (HFE) composed of Alnus hirsuta,
KKAy mouse, a genetic animal model of diabetes mellitus, is characterized by not only hyperglycemia, but also polydipsia and polyuria like human diabetes mellitus. In this study, we investigated the effects of Byakko-ka-ninjin-to (BKN), Bofu-tsusho-san (BOF) and Gorei-san (GRE) on blood glucose