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polygodial/necrosis
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3 results
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
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OBJECTIVE
To determine the molecular mechanisms of Shugan decoction (SGD) in the regulation of colonic motility and visceral hyperalgesia (VHL) in irritable bowel syndrome (IBS).
METHODS
The chemical compounds contained in SGD were measured by high-performance liquid chromatography. A rat model of
Antigrowth activity and induction of apoptosis in human melanoma cells by Drymis winteri forst extract and its active components.
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Melanoma is a highly invasive cancer that resists most conventional treatments. Therefore, there is an urgent need to identify alternative anticancer agents able to affect new molecular targets. Drimys winteri (Winteraceae) is a medicinal plant, employed in Brazil and many countries, in folk
Selective killing of proinflammatory synovial fibroblasts via activation of transient receptor potential ankyrin (TRPA1).
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BACKGROUND
Studies in rheumatoid arthritis synovial fibroblasts (RASF) demonstrated the expression of several transient receptor potential channels (TRP) such as TRPV1, TRPV2, TRPV4, TRPA1 and TRPM8. Upon ligation, these receptors increase intracellular calcium but they have also been linked to
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