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porphyria cutanea tarda/nicotine
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A case of porphyria cutanea tarda in the setting of hepatitis C infection and tobacco usage.
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Porphyria cutanea tarda (PCT) is the most common type of porphyria, presenting in middle-aged patients with a photodistributed vesiculobullous eruption, milia, and scars. Porphyria cutanea tarda occurs in relation to inhibition of uroporphyrinogen decarboxylase, a key enzyme in the heme biosynthesis
CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda.
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Porphyria cutanea tarda (PCT) is a cutaneous porphyria with sporadic (type 1) and familial (type 2) subtypes, both resulting from decreased hepatic uroporphyrinogen decarboxylase (UROD) activity. Environmental and genetic factors are involved in the development of PCT, and genetic variants in the
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