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porphyrias/seizures
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[Polyneuropathy and epileptic seizures in a family with acute intermittent porphyria].
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Report on clinical and electrophysiological findings in four members of a family with acute intermittent porphyria in the remission period. One patient had suffered from repeated epileptic seizures of the grand-mal type since the age of 24 years. Generalized and multifocal epileptic potentials were
Seizure management in acute hepatic porphyria: risks of valproate and clonazepam.
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Seizures may occur in acute intermittent porphyria or other hepatic porphyrias. Management is difficult, because barbiturates and hydantoins exacerbate the porphyric state. We studied one patient with major motor seizures and acute intermittent porphyria. The seizure disorder was exacerbated by
Acute intermittent porphyria, seizures, and antiepileptic drugs: a report on a 3-year-old Nigerian boy.
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A 3-year-old Nigerian boy was treated with phenobarbitone after having a nonfebrile seizure. Two weeks later his urine was found to contain porphobilinogen, indicating that latent acute intermittent porphyria had been unmasked by phenobarbitone. The drug was discontinued and carbamazepine was
Grand mal seizures and acute intermittent porphyria. The problem of differential diagnosis and treatment.
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A 36-year-old white man had both acute intermittent porphyria and long-standing idiopathic grand mal seizures. Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria. Comparison of urinary levels of the porphyrin precursors,
Melatonin and epileptic seizures in patients with acute intermittent porphyria.
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The objective of this study was to assess melatonin production in patients with acute intermittent porphyria (AIP), with and without known epileptic seizures, as a guide to whether melatonin may have anti-convulsive or pro-convulsive effects in AIP. Melatonin concentration in urine, sampled over
Epidemiology and clinical characteristics of seizures in patients with acute intermittent porphyria.
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The objectives of this study were to investigate the lifetime prevalence of epileptic seizures in a population with acute intermittent porphyria (AIP) and to characterize the seizures and the seizure-triggering factors. A letter was sent to all patients with known AIP in Sweden registered at the
Treatment of seizures in acute intermittent porphyria: safety and efficacy of gabapentin.
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Treatment of seizures in acute intermittent porphyria represents a therapeutic dilemma. Patients needing chronic therapy often experience acute porphyric attacks due to increased hepatic metabolism induced by the antiepileptic drugs themselves. Gabapentin is a new antiepileptic drug not appreciably
Gabapentin treatment of seizures in acute intermittent porphyria.
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Most antiepileptic drugs (AEDs) available have demonstrated porphyrogenicity in hepatic porphyrias. Gabapentin is a new AED not appreciably metabolized by the liver in humans. We report two patients with acute intermittent porphyria successfully treated with gabapentin without its inducing porphyric
Acute idiopathic porphyria: abdominal pain, convulsions and agitated depression.
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Seizure management in the hepatic porphyrias: results from a cell-culture model of porphyria.
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[Acute intermittent porphyria with cerebral manifestations: generalized convulsions with focal EEG abnormalities in one case; catatonic state in another case].
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Acute intermittent porphyria with seizure and paralysis in the puerperium.
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Seizures in experimental porphyria.
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Seizure management and hepatic porphyrias.
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Gabapentin in seizures due to acute intermittent porphyria.
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