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primary ovarian insufficiency/obesity
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Unbalanced translocation in an adult patient with premature ovarian failure and mental retardation detected by spectral karyotyping and array-comparative genomic hybridization.
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BACKGROUND
There are only three cases of unbalanced translocation (X;1) reported in childhood in the literature, while no such phenotypic information is available in adults.
METHODS
To delineate the phenotype-genotype relationship of unbalanced translocation (X;1) in adulthood, we reported here a
Risk for developing osteoporosis in untreated premature menopause.
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The bone mineral density (BMD) of the lumbar spine and proximal femur was determined by dual photon absorptiometry in 32 women with untreated premature menopause (cessation of menses before 45 years of age). The BMD of the spine and proximal femur in four obese patients was not different from the
The clinical and biochemical characteristics associated with insulin resistance in non-obese young women.
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OBJECTIVE
The aim of this study was to investigate the biomarkers of insulin resistance in non-obese women.
METHODS
This was a retrospective study.
METHODS
A total 229 non-obese women (Body mass index: BMI < 25) were evaluated.
METHODS
Serum levels of various androgens, cardiovascular risk and
[Atypical presentation of a premature ovarian failure with deletion of X chromosome].
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In order to illustrate a particular clinical presentation of premature ovarian failure, we report the case of a 16-year-old girl, who presented with primary amenorrhea. Physical examination discovered central obesity and an extent acanthosis nigricans in the neck and in the axillae. Pubertal stage
Impact of obesity on ovotoxicity induced by 7,12-dimethylbenz[a]anthracene in mice.
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Insulin, elevated during obesity, regulates xenobiotic biotransformation enzymes, potentially through phosphatidylinositol 3-kinase (PI3K) signaling, in extraovarian tissues. PI3K regulates oocyte viability, follicular activation, and ovarian chemical biotransformation.
Primary ovarian insufficiency: relation to changes in body composition and adiposity.
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There are several causes of primary ovarian insufficiency (POI) but all result in a premature cessation of female reproductive potential, mimicking the normal menopause. In normal menopause, there is increased cardiovascular risk associated with changes in body composition (specifically increasing
Altered m 6 A modification is involved in up-regulated expression of FOXO3 in luteinized granulosa cells of non-obese polycystic ovary syndrome patients
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The pathophysiology of polycystic ovary syndrome (PCOS) is characterized by granulosa cell (GC) dysfunction. m6 A modification affects GC function in patients with premature ovarian insufficiency (POI), but the role of m6 A modification in PCOS is unknown. The purpose of the
Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations.
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Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1-F3) following ancestral exposure during fetal gonadal sex determination. The current study was designed to determine if a mixture of plastic derived endocrine
The LIFESTYLE study: costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial.
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BACKGROUND
In the Netherlands, 30% of subfertile women are overweight or obese, and at present there is no agreement on fertility care for them. Data from observational and small intervention studies suggest that reduction of weight will increase the chances of conception, decrease pregnancy
Is AMP-Activated Protein Kinase associated to the metabolic changes in Primary Ovarian Insufficiency?
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Primary Ovarian Insufficiency (POI) is a critical fertility defect characterized by anticipated impairment of the follicular reserve which pathophysiological mechanisms have not yet been identified. We have investigated the possible relationship between AMPK and the pathophysiology of POI. We
Serum anti-Müllerian hormone (AMH) levels are differentially modulated by both serum gonadotropins and not only by serum follicle stimulating hormone (FSH) levels.
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It is generally accepted that serum AMH levels are thought to reflect the size of the ovarian follicle pool. Therefore, an inverse correlation between serum AMH and Follicle Stimulating Hormone (FSH) levels has been noted in older women with abnormal or exhausted follicular development, such as
[Risk factors and the course of myocardial infarction in elderly women].
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OBJECTIVE
to elucidate risk factors and special features of myocardial infarction (MI) in elderly women.
METHODS
We included into the study 217 women aged 34 to 89 years who had Q-wave or non Q-wave MI and were admitted for treatment in the cardiology department. These patients were divided into two
Peripherin-IgG association with neurologic and endocrine autoimmunity.
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Peripherin-IgG has been reported a pertinent autoantibody in non-obese type 1 diabetic (NOD) mice. However, it has not previously been recognized in any human disease. In blinded evaluation of serum for markers of neurological autoimmunity in a high-volume diagnostic laboratory, we incidentally
Leg ulcer in Werner syndrome (adult progeria): a case report.
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Werner syndrome (WS; MIM#277700) or adult progeria, is a rare disease, associated with mutations of a single gene (RECQL2 or WRN), located on chromosome 8 (8p12). It codes a DNA-helicase, whose defects cause genomic instability. The highest incidences are reported in Japan and Sardinia (Italy). On
Effects of ovarian failure and X-chromosome deletion on body composition and insulin sensitivity in young women.
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OBJECTIVE
Menopause is associated with increased visceral adiposity and reduced insulin sensitivity. It remains unclear whether these changes are due primarily to ovarian failure or aging. The aim of this study was to clarify the impact of ovarian failure on body composition and insulin sensitivity
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