primary ovarian insufficiency/tripterygium

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A woman with premature ovarian failure induced by Tripterygium wilfordii Hook.f. gives birth to a healthy child.

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OBJECTIVE To inform clinicians about the reproductive damage of Tripterygium wilfordii Hook.f. (TW) associated with subsequent premature ovarian failure. METHODS Case report. METHODS Reproductive medicine center in a university-affiliated hospital. METHODS A 36-year-old infertile woman presenting

[Establishment of premature ovarian insufficiency kidney deficiency and blood stasis pattern mouse model with Tripterygium wilfordii polyglycoside for Bushen Culuan Decoction therapy].

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To establish a mouse model of premature ovarian insufficiency( POI) with kidney deficiency and blood stasis pattern by Tripterygium wilfordii polyglycoside( TWP) gavage,and to evaluate the ovarian function and fertility of the model,in order to find Bushen Culuan Decoction therapeutic mechanism. 60

Tripterygium glycosides induce premature ovarian failure in rats by promoting p53 phosphorylation and activating the serine/threonine kinase 11-p53-p21 signaling pathway.

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Premature ovarian failure (POF) is a typical pathological disease of the reproductive system in aging females. Infection, inflammation, immune abnormalities, genetic mutation, radiotherapy and chemotherapy can cause POF. Tripterygium glycosides (TGs) are a component extracted from the Chinese herb

Mechanism of resveratrol in improving ovarian function in a rat model of premature ovarian insufficiency.

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OBJECTIVE To investigate the mechanism of resveratrol treatment in chemically induced premature ovarian insufficiency (POI) in rats. METHODS Five-week-old specific pathogen-free healthy Sprague-Dawley female rats (n = 90) were randomly divided into five groups (n = 18): low-dose resveratrol (group

Successful pregnancy with tripterygium glycoside-induced premature ovarian insufficiency: a case report.

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Premature ovarian insufficiency is characterized by reduced ovarian function in a young woman, resulting in an earlier menopause compared with women with normal ovarian function. It is a term that reflects the variable nature of the condition and is substantially less emotive than the formerly used

Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure.

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BACKGROUND To assess the therapeutic effect of Tongmai Dasheng Tablet (TMDST) on tripterygium glycosides (TG) induced premature ovarian failure (POF) rat model and investigate the underlying mechanisms, based on the establishing method of POF model we developed in our previous work. METHODS Rats

A mouse model of premature ovarian insufficiency induced by tripterygium glycoside via subcutaneous injection.

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Premature ovarian insufficiency (POI) is a main cause of infertility and affects nearly 1% women under 40 years old. This study was aimed to utilize the side effects of tripterygium glycoside (TG) to induce a mouse model of POI. 48 female KM mice were divided into four groups: control, oral,

Effects of Bushen Tianjing Recipe in a rat model of tripterygium glycoside-induced premature ovarian failure.

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BACKGROUND Bushen Tianjing Recipe (BTR) is a traditional Chinese herbal medicine that has been prescribed for premature ovarian failure (POF) for decades in China. Nevertheless, little is known regarding its underlying molecular mechanism. In the present study, we investigated the effects of BTR in

Induction of miR-15a expression by tripterygium glycosides caused premature ovarian failure by suppressing the Hippo-YAP/TAZ signaling effector Lats1.

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Tripterygium glycosides (TGs) are chemotherapeutic drugs and immunosuppressant agents for the treatment of cancer and autoimmune diseases. We have previously reported that TGs induces premature ovarian failure (POF) by inducing cytotoxicity in ovarian granulosa cells (OGCs). Hence, we report that

Melatonin protects premature ovarian insufficiency induced by tripterygium glycosides: role of SIRT1.

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Melatonin confers protective effects on premature ovarian insufficiency (POI) induced by tripterygium glycosides (TG) by reducing oxidative stress. Silent information regulator 1 (SIRT1) signaling is found to be associated with the physiology and pathology of ovary. We hypothesize that melatonin

Biochemical changes of oxidative stress in premature ovarian insufficiency induced by tripterygium glycosides.

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Premature ovarian insufficiency (POI) is one of clinical manifestations of ovarian damage. This study is to evaluate biochemical changes of oxidative stress in POI induced by tripterygium glycosides (TG) via subcutaneous injection. 24 female KM mice were assigned to two groups: control group and TG

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