Treatment of wild-type S49 murine lymphoma cells with 50 mM ethanol for 24 hr caused a 14% decrease in the Gs activity (an ability to compensate the deficiency of stimulatory GTP-binding regulatory protein, Gs, in membrane from CYC-S49 murine lymphoma cells) and a 29% decrease in the amount of
In continuation of our effort to optimize the pharmacological profile of [1,2-diamino-1,2-bis(4-fluorophenyl)ethane]dichloridoplatinum(II) complexes, we synthesized [1,2-diamino-1-(4-fluorophenyl)alkanol]dichloridoplatinum(II) analogs. The aim of this study was to evaluate the influence of hydroxyl
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