plasma (4 aliquots), serum (4 aliquots), packed cells pellets (5 aliquots) for each patient

HIV/AIDS

Infectious Diseases Institute

Outcomes of HIV Infected Individuals After Ten Years on Antiretroviral Treatment

A cross sectional analysis at study enrollment will be performed to characterize the clinical profile of patients after at least 9 years on ART including CD4 cell count, viral loads, WHO state, history of OIs, previous use of ART, level of anemia, and other medical conditions, drug mutations.

To determine the incidence of side effects and drug toxicity, requirement for drug switches, development of opportunistic infections (OIs) (in particular tuberculosis), morbidity (particularly non HIV related morbidity such as cancer and cardiovascular diseases), medication adherence and loss to follow up; to determine the relationship between various clinical and demographic variables at initiation of treatment and cohort enrollment and subsequent outcome.

To investigate causes of mortality using a standardized collection tool for verbal autopsies

To assess sexual behavior and sexual networks by routinely administered questionnaires through nurse counselors as well as to document over time the sero-status of the partners.

To investigate drug-drug interactions between antiretroviral drugs and concomitant medicines that are used by a sub-group of cohort subjects

To investigate cost (cost analysis) of care of patients on long term ART and compare it with the cost of care of patients on short and middle (<10 years) ART.

Principal Investigator

proteinuria/dental caries

Outcomes of HIV Infected Individuals After Ten Years on Antiretroviral Treatment

Dose-Dependent Effect of Thiazide in Dent's Disease Hypercalciuria

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