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proteinuria/inflammation
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Tissue targeted complement modulators
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I. BACKGROUND OF THE INVENTION
Complement is the collective term for a series of blood proteins and is a major effector mechanism of the immune system. Complement activation and its deposition on target structures can lead to direct complement-mediated cell lysis, or can lead indirectly to cell or
Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
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BACKGROUND OF THE INVENTION
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-.alpha. converting enzyme (TACE, tumor necrosis factor-.alpha. converting enzyme)
Preparation and use of ortho-sulfonamide heteroarly hydroxamic acids as matrix metalloproteinase and TACE inhibitors
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BACKGROUND OF THE INVENTION
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-.alpha. converting enzyme (TACE, tumor necrosis factor-.alpha. converting enzyme)
Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metaloproteinase and tace inhibitors
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BACKGROUND OF THE INVENTION
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-.alpha. converting enzyme (TACE, tumor necrosis factor-.alpha. converting enzyme)
Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
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BACKGROUND OF THE INVENTION
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-.alpha. converting enzyme (TACE, tumor necrosis factor-.alpha. converting enzyme)
Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
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BACKGROUND OF THE INVENTION
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-.alpha. converting enzyme (TACE, tumor necrosis factor-.alpha. converting enzyme)
Preparation and use of .beta.-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors
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BACKGROUND OF THE INVENTION
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-.alpha. converting enzyme (TACE, tumor necrosis factor-.alpha. converting enzyme)
Biaryl acetylenes as inhibitors of matrix metalloproteases
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to enzyme inhibitors, and more particularly, to novel biaryl acetylene containing compounds or derivatives thereof useful for inhibiting matrix metalloproteases.
2. Description of the Related Art
The matrix metalloproteases
Use of citral for treating focal segmental glomerulosclerosis
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RELATED APPLICATIONS
This application claims the benefit of Taiwan Patent Application No. 102113187, filed on Apr. 12, 2013, the entire content of which is incorporated herein by reference.
TECHNOLOGY FIELD
The present invention relates to use of citral for treating focal segmental
Inhibition of matrix metalloproteases by substituted phenalkyl compounds
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This patent application claims priority from U.S. provisional application, which was converted from U.S. application Ser. No. 08/645,026, filed May 15, 1996, to a provisional application by a petition under 37 C.F.R. .sctn.1.53(b) (2) (ii) filed on May 14, 1997.
BACKGROUND OF THE INVENTION
1. Field
Cyclohexenone compounds from Antrodia camphorata to treat autoimmune diseases
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to compounds for the treatment of immune-related diseases, in particular to cyclohexenone compounds isolated and purified from Antrodia camphorata extracts and can be applied in treatment of autoimmune immune
Compositions and methods of use for (pro)renin receptor
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REFERENCE TO SEQUENCE LISTING
The Sequence Listing submitted Aug. 1, 2014 as a text file named "21101_0299U3_Sequence_Listing.txt," created on Aug. 1, 2014, and having a size of 12,687 bytes is hereby incorporated by reference pursuant to 37 C.F.R. .sctn.1.52(e)(5).
BACKGROUND
Hypertension is the
Inhibition of matrix metalloproteases by substituted biaryl oxobutyric acids
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to enzyme inhibitors, and more particularly, to novel substituted biaryl oxobutyric acid compounds or derivatives thereof useful for inhibiting matrix metalloproteases.
2. Description of the Related Art
The matrix
Inhibition of matrix metalloproteases by substitued biaryl oxobutyric acids
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to enzyme inhibitors, and more particularly, to novel substituted biaryl oxobutyric acid compounds or derivatives thereof useful for inhibiting matrix metalloproteases.
2. Description of the Related Art
The matrix
Inhibition of matrix metalloproteases by substituted biaryl oxobutyric acids
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to enzyme inhibitors, and more particularly, to novel substituted biaryl oxobutyric acid compounds or derivatives thereof useful for inhibiting matrix metalloproteases.
2. Description of the Related Art
The matrix
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