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protoveratrine/hemorrhage

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Circulatory and respiratory consequences of massive hemorrhage are reversed by protoveratrines.

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In a rat model of severe hypotension and respiratory depression induced by step-wise bleeding, protoveratrines cause a prompt and sustained improvement of cardiovascular and respiratory functions, both in anesthetized and in conscious animals, seemingly through a magnification of the reflex response

The opioid/anti-opioid balance in shock: a new target for therapy in resuscitation.

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Teleologically, pain is of paramount importance for survival and induces the organism to cope in an active way with aggressions from a basically hostile environment. While the activation of endogenous analgesic (opioid) systems typically occurs in conditions of surrender (pre-terminal conditions,
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