Alpha-naphthoxyacetic acid (alpha-NOAA), one of the jumping-inducers, elicited a dose-dependent retching behavior at doses ranging from 250 to 550 mg/kg in mice and vomiting at a dose of 550 mg/kg in pigeons. Protoveratrine-A (PV-A, 0.1 mg/kg), a veratrum alkaloid, also induced retching in mice and
The antiemetic activity of zacopride against a variety of emetogenic agents has been determined in dogs. Zacopride was highly effective in inhibiting emesis due to a wide range of cancer chemotherapeutic agents, particularly cisplatin. It was well absorbed orally since the dose of zacopride required
The organization of the central neuronal circuitry that produces vomiting was explored by mapping the distribution of c-fos protein (Fos)-like immunoreactivity (FLI) as a monitor of functional activity. The brainstem and spinal cord were examined in cats administered multiple emetic drugs
A 49-year-old man consumed two glasses (approximately 2 x 20 mL) of a beverage containing yellow gentian (Gentiana lutea). Shortly after ingestion, he developed nausea, vomiting, and oral paraesthesia. On admission to the hospital he suffered from severe bradycardia (35 beats/min) and hypotension
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