pulmonary heart disease/proline

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Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia.

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BACKGROUND Xanthine oxidoreductase (XOR) is involved in oxidative metabolism of purines and is a source of reactive oxygen species (ROS). As such, XOR has been implicated in oxidant-mediated injury in multiple cardiopulmonary diseases. XOR enzyme activity is regulated, in part, via a

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