The etiologic agent of Q fever Coxiella burnetii, is an intracellular obligate parasite that develops large vacuoles with phagolysosomal characteristics, containing multiple replicating bacteria. We have previously shown that Phase II C. burnetii replicative vacuoles generated after 24-48 h post
Coxiella burnetii, the etiological agent of Q fever, possesses immunomodulatory activity which positively and negatively regulates host immune responses. We wish to determine the Coxiella strain differences and the chemical nature of cellular components suppressing lymphocyte responsiveness. The
The etiological agent of Q fever is Coxiella burnetii , an obligate intracellular Gram-negative bacterium and the only bacterium known to date that survives and replicates within a vacuole of phagolysosomal characteristics. In humans, Q fever is characterized by a wide spectrum of clinical
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