All participants will undergo fetoscopic repair of fetal spina bifida.

Spina Bifida

Myelomeningocele

Chiari Malformation Type 2

Neural Tube Defects

Spinal Dysraphism

Congenital Abnormality

Fetoscopy

Johns Hopkins Hospital

Fetoscopic Repair of Isolated Fetal Spina Bifida

Study of Fetoscopic Repair of Myelomeningocele in Fetuses With Isolated Spina Bifida

Successful complete closure of the defect fetoscopically and reversal of hindbrain herniation on ultrasound and MRI prior to delivery

Preterm premature rupture of membranes occuring any time from surgery until 37 weeks of gestation

Preterm labor occuring at any time from surgery leading to delivery before 34 weeks of gestation

Gestational age of delivery regardless of indication

Mode of delivery - either vaginal or cesarean section

Need for a cerebrospinal fluid shunt within the first year of life

Score of the Mental Developmental Index of the Bayley Scales of Infant Development II at 30 months of age. The score ranges from 50 (minimum) to 150 (maximum). A score of <70 indicates severe developmental delay; 70-84 indicates moderate delay; >85 indicates no delay.

Difference between the anatomic upper border of the lesion level and motor function based on the physical examination at 30 months of age. A positive score of 2 indicates a functional level 2 vertebrae higher than lesion level. A score of -2 indicates a function level 2 vertebrae lower than the lesion level.

Collaborate in the International Fetoscopic Neural Tube Defect (NTD) Consortium - A Limited Data Set will be entered into a website maintained by Baylor College of Medicine. The data will be combined with data provided by other members of the Consortium to provide a comprehensive Data Base that will be accessible by all Consortium members.

Johns Hopkins University

This is a single arm clinical study. All participants will undergo laparotomy with exteriorization of the uterus followed by minimally-invasive, fetoscopic repair of the fetal spina bifida lesion.

quadriplegia/edema

Fetoscopic Repair of Isolated Fetal Spina Bifida

The most complete medicinal herbs database backed by science