rauvolfia verticillata/anticancer

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Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway.

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Nuclear factor erythroid-2 related factor 2 (Nrf2) is a crucial transcription factor that regulates the expression of defensive antioxidants and detoxification enzymes in cells. In a previous study, we showed that expression of the Nrf2 gene is regulated by an epigenetic modification. Rauvolfia

Cytotoxic yohimbine-type alkaloids from the leaves of Rauvolfia vomitoria

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Two new yohimbine-type monoterpene indole alkaloids rauvine A and B ( 1 - 2 ) and six known derivatives ( 3 - 8 ) were obtained from the leaves of R. vomitoria . The structures of the two new alkaloids were determined by extensive spectroscopic analyses, 13 C NMR and ECD calculations. This is the

Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells.

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One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon

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