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Association between severity of gastrointestinal prodrome and long-term prognosis in classic hemolytic-uremic syndrome.

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To determine whether severity of the prodromal gastrointestinal illness is associated with the course and complications of the extraintestinal manifestations of hemolytic-uremic syndrome, we conducted a retrospective review of children (n = 509) hospitalized with hemolytic-uremic syndrome. Those who

Ornithine Transcarbamylase Deficiency: If at First You Do Not Diagnose, Try and Try Again.

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Ornithine transcarbamylase (OTC) deficiency is well known for its diagnosis in the neonatal period. Presentation often occurs after protein feeding and manifests as poor oral intake, vomiting, lethargy progressing to seizure, respiratory difficulty, and eventually coma. Presentation at adulthood is

Comparison of acute bloody and watery diarrhea: a case control study.

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The clinical and laboratory findings of 290 cases of bloody diarrhea who presented to the department of Diarrhea Training and Treatment between June 1998 and May 2002 were investigated, and compared to those of two consecutive cases who had watery diarrhea. The bloody diarrhea group had higher mean

Predictors of mortality in children hospitalized with dysentery in Harare, Zimbabwe.

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OBJECTIVE To document the pattern of complications and identify risk factors for subsequent mortality in a hospitalized paediatric population during a Shigella dysenteriae type 1 epidemic. METHODS Hospital based prognostic study. METHODS Paediatric wards in Harare and Parirenyatwa tertiary referral

Prognostic indicators in haemolytic uraemic syndrome.

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OBJECTIVE This study aims to review the clinical presentations of Haemolytic Uraemic Syndrome (HUS) and to compare the poor prognostic indicators with mortality. METHODS Prospective study carried out in Renal Dialysis ward of Dhaka Shishu Hospital, Bangladesh from September 2001 November 2003 for a

Post-dysenteric hemolytic uremic syndrome in children during an epidemic of Shigella dysentery in Kwazulu/Natal.

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We report 81 of 107 cases of hemolytic uremic syndrome (HUS), admitted between July 1994 and February 1996, following an outbreak of Shigella dysenteriae type 1 dysentery in Kwazulu/Natal. All patients, excluding 1, were black with a mean age of 38 months (range 1-121); 50 (61.7%) were males. The

Gastrointestinal and extra-intestinal manifestations of childhood shigellosis in a region where all four species of Shigella are endemic.

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OBJECTIVE To determine the clinical manifestations and outcome of shigellosis among children infected with different species of Shigella. METHODS We identified all patients <15 years infected with Shigella admitted to the icddr, b Dhaka hospital during one year. Study staff reviewed admission

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype.

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The membrane transporter AT-1/SLC33A1 translocates cytosolic acetyl-CoA into the lumen of the endoplasmic reticulum (ER), participating in quality control mechanisms within the secretory pathway. Mutations and duplication events in AT-1/SLC33A1 are highly pleiotropic and have been linked to diseases

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