rhabdoid tumor/phosphatase

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[Clinicopathologic and immunohistochemical study of atypical teratoid/rhabdoid tumor of central nervous system].

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OBJECTIVE To study the clinicopathologic features and differential diagnosis of atypical teratoid/rhabdoid tumor (AT/RT) occurring in the central nervous system. METHODS Two cases of AT/RT were studied by hematoxylin-eosin, reticulin and immunohistochemical staining. The clinical and pathologic

Primary Intracranial Atypical Teratoid/Rhabdoid Tumors: A Clinicopathologic and Neuroradiologic Study.

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Atypical teratoid/rhabdoid tumors are rare malignant pediatric brain tumors. This study was performed to characterize the clinicopathologic and neuroradiologic characteristics of atypical teratoid/rhabdoid tumors from 8 patients, including 5 male and 3 female infants (median age, 67 months).

Activation of Akt/mTOR pathway in a patient with atypical teratoid/rhabdoid tumor.

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A typical teratoid/rhabdoid tumor (AT/RT) is a highly malignant childhood brain tumor. Most AT/RTs are shown to contain chromosome 22 mutation in the region of hSNF5/INI1 gene, whose protein product participates in chromatin remodeling. Although the presence of this mutation is well described,

[Atypical teratoid/rhabdoid tumors of central nervous system in childhood: a clinical and histopathologic study of 6 cases].

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OBJECTIVE To study the clinicopathologic features, immunohistochemical findings, diagnosis and differential diagnosis of atypical teratoid/rhabdoid tumors (AT/RT) of central nervous system in childhood. METHODS The clinicopathologic data, morphologic features and immunophenotypes were reviewed in 6

High-molecular-mass or macromolecular alkaline phosphatase in sera of children with solid tumors.

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High-molecular-mass alkaline phosphatase (H-Mr AP) was detected in sera from children with solid tumors without liver metastases. H-Mr AP activities were determined by a liquid chromatographic and an electrophoretic method. In 5 out of 10 cases with solid tumors--Ewing sarcoma (n = 2), neuroblastoma

Malignant rhabdoid tumors express stem cell factors, which relate to the expression of EZH2 and Id proteins.

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Malignant rhabdoid tumors (MRTs) are highly aggressive pediatric tumors associated with loss of expression of SMARCB1, commonly occurring in the central nervous system [referred to as atypical teratoid/rhabdoid tumors (AT/RTs)] and in the kidney and soft tissues. Histologically, MRTs are

Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG.

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The homeodomain transcription factor, NANOG, along with OCT3/4 (POU5F1) and SOX2, is part of the core set of transcription factors that maintain embryonic stem cell self-renewal and pluripotency. Expression of NANOG has been detected in fetal germ cells and in gonadal germ cell tumors. To assess the

New immunohistochemical markers in the evaluation of central nervous system tumors: a review of 7 selected adult and pediatric brain tumors.

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BACKGROUND Immunohistochemistry (IHC) has become an important tool in the diagnosis of brain tumors. OBJECTIVE To review the latest advances in IHC in the diagnostic neuro-oncologic pathology. METHODS Original research and review articles and the authors' personal experiences. RESULTS We review the

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