Pulpitis - Irreversible

Administration of ketorolac 10mg, (Dolac) 15 minutes before the clinical procedure.

one dose ketorolac 10 mg

Administration of diclofenac, (Diclofenaco) 15 minutes before the clinical procedure.

One dose Diclofenac

Administration of Placebo, 15 minutes before the clinical procedure.

Placebo oral capsule

Jose Clemente

The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo

The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo on Postoperative Pain in Teeth With Irreversible Pulpitis and Apical Periodontitis

One dose administration before the RCT done

Invitation to participate. Offer to the public All the clinical procedure and risks were explained to each participant.

Jorge Paredes Vieyra

Principal Investigator. PhD

Universidad Autonoma de Baja California

Patient selection.
Fifty-four of sixty-five patients (29 women and 25 men), 18 to 60 years of age with 54 eligible teeth consented to participate in the study. The patients were randomly divided into three groups using a web program. The patient number and group number were recorded. Informed consent was obtained from each patient and the possible discomforts and risks were fully explained.
A total of 54 patients were divided into three groups (n = 18) according to the type of preoperative drug administrated.

Patient selection.
Fifty-four of sixty-five patients (29 women and 25 men), 18 to 60 years of age with 54 eligible teeth consented to participate in the study. The patients were randomly divided into three groups using a web program. The patient number and group number were recorded. Informed consent was obtained from each patient and the possible discomforts and risks were fully explained.
A total of 54 patients were divided into three groups (n = 18) according to the type of preoperative drug administrated, as follows: Group A: Administration of ketorolac 10mg, Group B: Administration of Diclofenac Na 50mg, and Group C: A placebo (capsule filled with sugar).
After 15 minutes each participant received the treatment.

(FS-SMILE )femtosecond small incision lenticule extraction procedure using Visumax laser device as a surgical intervention for correction of myopia and myopic astigmatism will be done for 30 eyes of patients with myopia or myopic astigmatism.

(FS-LASIK)femtosecond assisted LASIK procedure using Fs200 laser device as a surgical intervention for correction of myopia and myopic astigmatism will be done for 30 eyes of patients with myopia or myopic astigmatism.

Myopia

The procedure will be performed using an established technique. the patient's eye will be centered and docked with the curved interface cone before application of suction fixation.The laser will be activated for photo-dissection in the following sequence: first the posterior surface of the refractive lenticule then the lenticule border then The anterior surface of the refractive lenticule which extended beyond the posterior lenticule diameter by 0.5 mm to form the anterior flap and is followed by a rim cut. After the suction is released, a Siebel spatula is inserted under the cap near the hinge before the cap is separated. The edge of the refractive lenticule is separated from the stromal bed with a sinsky hook and the posterior border of the lenticule gently separated with the Siebel spatula. The lenticule is then grasped with forceps through the small incision.

FS-SMILE

LASIK procedure Each LASIK procedure will be performed using a standard, established technique. Under topical anesthesia and standard draping, a lid speculum is used to retract the eyelids. A superiorly hinged 100 μm thick flap will be created using the WaveLight FS200 (Alcon Laboratories, Inc.) With inverted side cut (115 ̊) .Excimer laser ablation is then performed using WaveLight EX500 excimer laser (Alcon Laboratories, Inc.).After ablation, the flap will be carefully repositioned, and postoperative medications are commenced.

FS- LASIK

Visumax device

FS 200 device

Kasr Alainy Hospital

Comparison Between FS- LASIK and FS-SMILE for Correction of Myopia and Myopic Astigmatism

Comparison Between Femtosecond Assisted LASIK and Small Incision Lenticule Extraction (SMILE) for Correction of Myopia and Myopic Astigmatism

• Refractive predictability, which is defined as the proportion number of eyes achieving a postoperative spherical equivalent (SE) within ±0.50 D of the intended target.

Efficacy: defined as the proportion number of eyes achieving an unaided visual acuity (UDVA) of 20/20 or better postoperatively (efficacy= postoperative UCVA/preoperative BCVA %).

Safety: defined as the proportion number of eyes that lost or gained one or more lines of postoperative best corrected visual acuity (BCVA) relative to the preoperative BCVA (Safety= Postoperative BCVA/preoperative BCVA %)

corneal hysteresis will be measured by ORA device and the investigators will compare between the preoperative and postoperative results in both groups.

schirmer test and tear breack up time test will be tested pre and postoperatively and the investigators will compare between the preoperative and postoperative results in both groups.

corneal higher order aberrations( total RMS) will be measured and comparison between the preoperative and postoperative value will be conducted.

corneal resistance factor will be measured by ORA device and the investigators will compare between the preoperative and postoperative results in both groups.

tear breack up time test will be tested pre and postoperatively and the investigators will compare between the preoperative and postoperative results in both groups.

rhein/inflammation

The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo

Comparison Between FS- LASIK and FS-SMILE for Correction of Myopia and Myopic Astigmatism

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