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Potent antitumor effects of an antitumor endothelial cell immunotoxin in a murine vascular targeting model.

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Immunotoxins and other antibody-based therapeutic reagents have proved effective agonist lymphomas and leukemias, but results with carcinomas and other solid tumors have thus far been less impressive. A major reason for this difference is that macromolecules penetrate poorly and unevenly into solid

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