salicylate/atrophy

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Effect of salicylate on the surgical inducement of joint degeneration in rabbit knees.

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Degenerative joint changes were produced in one knee of each of fourteen rabbits by surgical induction of instability. The involved knee in rabbits with and without systemic salicylate treatment was compared with the knee not operated on. Salicylate did not significantly change the activities of

Salicylate-induced degeneration of cochlea spiral ganglion neurons-apoptosis signaling.

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Aspirin, whose active ingredient is sodium salicylate, is the most widely used drug worldwide, but it is not recommended for children because it may cause Reye's syndrome. High doses of salicylate also induce temporary hearing loss and tinnitus; while these disorders are believed to disappear when

Morphine deteriorates spatial memory in sodium salicylate treated rats.

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Tolerance and cross-tolerance for the effects of morphine (M) and sodium salicylate on nociception and learning were examined. The anti-nociceptive effects were measured by using the classic tail flick (TF) and hot plate (HP) tests and learning was measured with the Morris water maze (MWM).

Salicylate inhibition of cartilage degeneration.

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[Effect of sodium salicylate on the adrenal atrophy produced by cortisone].

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Effects of nimodipine on salicylate ototoxicity.

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The purpose of this study was to examine the effects of nimodipine on salicylate ototoxicity in guinea pigs. The compound action potential (CAP) was recorded at the round window, and the cochlear blood flow (CBF) was measured simultaneously from the lateral wall of the basal turn of the cochlea by

Novel pathway of salicylate degradation by Streptomyces sp. strain WA46.

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A novel salicylate-degrading Streptomyces sp., strain WA46, was identified by UV fluorescence on solid minimal medium containing salicylate; trace amounts of gentisate were detected by high-pressure liquid chromatography when strain WA46 was grown with salicylate. PCR amplification of WA46 DNA with

Iontophoretic Treatment of Hyperkeratosis with Sodium Salicylate.

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Ten patients having hyperkeratosis with moderate to severe fissures on palms and soles were treated with iontophoresis using 5-10% aqueous solution of sodium salicylate. The results were excellent within a period of 3-4 weeks (6-8 sittings each for a period of 10-15 minutes). The treatment was free

Anesthesia in a patient with undiagnosed salicylate poisoning presenting as intraabdominal sepsis.

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An 81-year-old woman with unintentional salicylate intoxication presented with features of sepsis, abdominal pain, and tenderness. Laparotomy was performed to rule out acute cholecystitis. Anesthesia was complicated by severe hypercarbia despite hyperventilation, and progressive cardiovascular and

Comparison of the effects of steroid, aspirin and sodium salicylate on articular cartilage.

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Rabbit knee joints were compressed to produce cartilage degeneration in control and test animals who received intramuscular injections of prednisolone and aspirin or sodium salicylate by gavage. After three weeks of compression, animals were sacrificed and articular cartilage was analyzed grossly

Effect of tissue degeneration on drug transfer across in vitro rat intestine.

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A modified rat intestinal sac technique involving a closed circulation of the mucosal drug solution through the lumen was developed with the aim of clarifying the influence of tissue degeneration on drug transfer in the current in vitro methods for studying intestinal absorption. Data on salicylate

Aspirin aggravates the degeneration of canine joint cartilage caused by immobilization.

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The effect of aspirin on the degeneration of knee cartilage caused by immobilization was examined. If dogs were fed aspirin daily (serum salicylate = 20-25 mg/dl) for 6 weeks while one hind limb was immobilized in a cast, the decreases in uronic acid content and net proteoglycan synthesis in

Optic atrophy after propoxyphene overdose: report of a case.

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An 18-year-old woman suffered cardiac arrest and became comatose after ingesting a large amount of proxyphene and salicylates. Six days after admission, her pupils, initially miotic, became fixed and dilated. On the seventh day disc edema developed. This was due to optic neuritis from acute Darvon

Sodium salicylate protects against rotenone-induced parkinsonism in rats.

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Complex I deficiency culminating in oxidative stress is proposed as one of the upstream mechanisms of nigral neuronal death in Parkinson's disease. We investigated whether sodium salicylate, an active metabolite of aspirin, could afford protection against rotenone-induced oxidative stress, neuronal

The effect of salicylate on prostaglandin levels in rabbit knees following inducement of osteoarthritic changes.

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Surgical inducement of medial instability in the right knee of rabbits was used to produce joint changes which resemble those observed in human osteoarthritis. Ordinary tap water was supplied to half of the rabbits and tap water plus sodium salicylate to the others. Determinations of prostaglandin

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