-Chemo-radiation enhances survival but also increases the risk of PRD. The result will be an increasing
- Cost for society (repeated hospitalization for palliative care)
- An ethical problem to help these patients with irreversible degraded quality of life.
Results from conventional therapies for
Cisplatin has the highest ototoxic potential of all platinum containing compounds. It is used in the treatment of squamous cell carcinoma of the head and neck, germ cell tumours of the testis and bladder carcinoma.
42% of 400 patients receiving high-dose cisplatin (70-85 mg/m2, median cumulative
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