salivary gland neoplasms/tyrosine

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The receptor tyrosine kinase inhibitor vandetanib activates Akt and increases side population in a salivary gland tumor cell line (A253).

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We and others have reported that cancer side population (SP) cells have self-renewal and multidrug resistance capabilities. These phenotypes are similar to those of cancer stem cells (CSCs), cancer stem-like cells and tumor-initiating cells (TICs). It has also been reported that upregulation of the

Tyrosine-rich crystals associated with oncocytic salivary gland neoplasms.

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OBJECTIVE Crystalloids have been identified ultrastructurally within the epithelial cells of Warthin's tumors, but there have been no studies characterizing crystals or crystalloids in Warthin's tumors by light microscopy. The finding of abundant needle-shaped crystals in a fine-needle aspirate of a

Tyrosine crystals in salivary gland tumours.

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Tyrosine crystals were seen in 24 of 113 salivary gland pleomorphic adenomas from Malawi and one of six carcinomas arising in a pleomorphic adenoma; they were present in tumours from all common anatomical sites. They were not found in 71 other salivary tumours of varying histological type. Similar

Tyrosine crystals in salivary gland tumours.

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Fluorescence in situ hybridization gene amplification analysis of EGFR and HER2 in patients with malignant salivary gland tumors treated with lapatinib.

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BACKGROUND Gene amplification status of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2) were analyzed and correlated with clinical outcome in patients with progressive malignant salivary glands tumors (MSGT) treated with the dual EGFR/Her2 tyrosine

Salivary gland cancer: an update on present and emerging therapies.

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Malignant salivary gland tumors make up a small proportion of malignancies worldwide, yet vary widely in terms of histology, patterns of spread, and recurrence. A better understanding of this variability will guide appropriate treatment recommendations and lead to improved outcomes. Recent molecular

Fibrous meningioma with tyrosine-rich crystals.

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A 58-year-old African-American woman presented with a 6-month history of headaches. A magnetic resonance imaging scan of the head revealed a 5-cm, enhancing dura-based mass in the left parietal region. The variably cellular tumor was composed of uniform spindle cells associated with intercellular

Meningioma With Tyrosine-Rich Crystalloids: A Case Report and Review of the Literature.

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We report a case of fibrous meningioma with tyrosine-rich crystalloid in the frontal lobe of a middle-aged woman. The patient presented with a history of several years of worsening headaches and blurry vision, which progressed to include syncopal episodes and right-sided weakness. Imaging

A case of clear cell meningioma with tyrosine-rich crystals.

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We present a case of clear cell meningioma with unusual clinical and pathologic features. The patient was a 54-year-old man who underwent laminectomy and durotomy for an intradural tumor in the lumbar spinal canal. Sections showed a predominance of dense collagenous tissue with irregularly shaped

The landscape of gene fusions and somatic mutations in salivary gland neoplasms - Implications for diagnosis and therapy.

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Recent studies of the genomic landscape of salivary gland tumors have provided important insights into the molecular pathogenesis of these tumors. The most consistent alterations identified include a translocation-generated gene fusion network involving transcription factors, transcriptional

Salivary gland tumors in Malawi.

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A study of 190 tumors of major and minor salivary glands seen in Malawi over a nine-year period showed an overall incidence rate similar to that in Western countries. However, submandibular and palatal tumors are relatively more common, parotid tumors more likely to be malignant, and submandibular

Immunohistochemical expression of the oncogenic molecules active Stat3 and survivin in benign and malignant salivary gland tumors.

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OBJECTIVE Signal transducer and activator of transcription 3 (Stat3) and survivin have been shown to exert oncogenic effects in various human neoplasms. The purpose of this study was to evaluate the expression of tyrosine phosphorylated (active) Stat3 and survivin in various benign and malignant

Tyrosine-rich crystalloids in neoplasms and tissues of the head and neck.

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Tyrosine-rich crystalloids were identified in three benign mixed tumors of the parotid gland, one terminal duct adenocarcinoma of a minor salivary gland, and the fibrous connective tissue of two laryngectomy specimens. Light and electron microscopic studies showed the crystalloids to be composed of

Simultaneous bilateral pleomorphic adenomas of the parotid glands with unilateral tyrosine rich crystalloids.

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A case of simultaneous, bilateral pleomorphic adenoma of the parotid glands following irradiation to the head and neck for childhood Hodgkin's disease is presented. The tumour on the side given the highest radiation exposure contained so-called tyrosine rich crystalloids (TRCs). Simultaneous

Tyrosine-rich crystalloids in a fine needle aspirate of a polymorphous low grade adenocarcinoma of a minor salivary gland. A case report.

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Tyrosine-rich crystalloids were identified in a fine needle aspirate of a polymorphous low grade adenocarcinoma of a minor salivary gland. Such crystalloids have been described previously as occurring in tissue sections of both benign and malignant salivary gland neoplasms and in the fine needle

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