schistosomiasis/triglyceride

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The acute schistosomiasis mansoni ameliorates metabolic syndrome in the C57BL/6 mouse model.

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Human and experimental studies have shown that chronic schistosomiasis mansoni protects against metabolic disorders through direct and indirect pathways. This study aims to investigate the co-morbidity between the acute schistosomiasis and nonalcoholic fatty liver. To address this, male C57BL/6 mice

[Clinical significance of changes of lipid in elderly patients with hepatic schistosomiasis].

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OBJECTIVE To explore the clinical significance of lipid levels including total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low density lipoprotein (LDL-C), and apolipoprotein (APOA I and APOB) of elderly patients with hepatic schistosomiasis. METHODS A total of 280

Influence of interleukin-2 and interferon-gamma in murine schistosomiasis.

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Schistosoma mansoni-infected mice were administered at the time of parasite residency in the lung with recombinant murine interleukin (IL)-2 or interferon-gamma (IFN-gamma), to evaluate the impact of cytokines in host responses to primary schistosomiasis. S. mansoni lung-stage schistosomula did not

ApoE deficiency promotes hepatic pathology by aggravating Th17/Treg imbalance in murine schistosomiasis japonica

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Aims: The Schistosoma japonicum (S. japonicum)-infected ApoE gene deficiency (ApoE^-/- ) mice were used to determine effect of ApoE on hepatic immunopathology. Methods:

Association between previous schistosome infection and incident hyperuricemia: A prospective cohort study in China.

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More than 11 million people were estimated to be infected by Schistosoma japonicum in China before the 1950s. However, seldom studies have been conducted to evaluate the longitudinal effects of previous schistosome infection (PSI). We aimed to investigate the association between PSI

Testicular lipids and serum FSH of mice in experimental Schistosomiasis mansoni.

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Morphological and histopathological changes in the testis have been reported to result from bilharzial infestation. There should be certain changes in the biochemical composition of the cells which might lead to these changes in the structure. This study was undertaken to compare the lipid

Potential long-term effects of previous schistosome infection may reduce the atherogenic index of plasma in Chinese men.

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The major purpose of this study was to assess the association between the potential long-term effects of previous schistosome infection and atherogenic dyslipidemia. Among 1597 men aged ⩾45 years who received health examinations and lived in previous schistosomiasis-endemic regions of China, 465

Human plasma lipid modulation in schistosomiasis mansoni depends on apolipoprotein E polymorphism.

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BACKGROUND Schistosomiasis mansoni is a parasitic liver disease, which causes several metabolic disturbances. Here, we evaluate the influence of Apolipoprotein E (APOE) gene polymorphism, a known modulator of lipid metabolism, on plasma lipid levels in patients with hepatosplenic

An evaluation of the marmoset Callithrix jacchus (sagüi) as an experimental model for the dyslipoproteinemia of human Schistosomiasis mansoni.

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Human infection with the parasite Schistosoma mansoni is a relatively common occurrence in regions of South America and is associated with liver dysfunction and dyslipoproteinemia. Specifically, the activity of plasma lecithin:cholesterol acyltransferase (LCAT) activity is reduced, the concentration

Effect of niridazole on the lipid pattern of the parasite and host tissues in experimental schistosomiasis mansoni.

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THE LIPID pattern of blood and liver of mice infected with S. mansoni as well as in male and female worms was studied. Experiments were also carried out on non-infected and infected mice after treatment with Niridazole. It was found that Niridazole caused a significant increase in liver

RELATION BETWEEN SCHISTOSOME PAST INFECTION AND METABOLIC SYNDROME.

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Schistosome antigens modulate host metabolic profiles in experimental animals. The effects of previous schistosome infection (PSI) and the development of metabolic syndrome remain unknown in humans. This study evaluated previous schistosome infection (PSI) related to metabolic syndrome (MS). A total

Natural Schistosoma mansoni Infection in the Wild Reservoir Nectomys squamipes Leads to Excessive Lipid Droplet Accumulation in Hepatocytes in the Absence of Liver Functional Impairment.

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Schistosomiasis is a neglected tropical disease of a significant public health impact. The water rat Nectomys squamipes is one of the most important non-human hosts in the schistosomiasis mansoni transmission in Brazil, being considered a wild reservoir. Cellular mechanisms that contribute to the

Is arachidonic acid an endoschistosomicide?

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Schistosoma mansoni and Schistosoma haematobium are intravascular, parasitic flatworms that infect >250 million people in 70 developing countries, yet not all people of the same community and household are afflicted. Regarding laboratory rodents, mice but not rats are susceptible to infection with

Schistosoma mansoni: relationship of tumor necrosis factor-alpha to morbidity and collagen deposition in chronic experimental infection.

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Chronic (20-week) Schistosoma mansoni infections in male CBA/J mice present as one of two pathophysiologic forms: severe hypersplenomegaly syndrome (HSS) or a less severe, moderate splenomegaly syndrome (MSS). HSS mice are cachectic (including anemia and hypertriglyceridemia) and exhibit high levels

Schistosoma mansoni: experimental chemoprophylaxis in mice using oral anti-penetration agents.

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The ability to prevent schistosomiasis by using an oral chemoprophylactic agent, which acts by preventing cercarial penetration, has been unexplored. We initially examined the effect of praziquantel (PZQ) as such an agent and found that it was moderately effective in blocking cercarial penetration,

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