sciatica/necrosis

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Tumor necrosis alpha-blocking agent (etanercept): a triple blind randomized controlled trial of its use in treatment of sciatica.

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METHODS Triple blind randomized controlled study. OBJECTIVE To establish the treatment effect of etanercept in acute sciatica secondary to lumbar disc herniation. BACKGROUND Etanercept is a selective competitor of tumor necrosis factor-alpha which is a proinflammatory cytokine. It is currently used

Tumor necrosis factor-α blockade in recurrent and disabling chronic sciatica associated with post-operative peridural lumbar fibrosis: results of a double-blind, placebo randomized controlled study.

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BACKGROUND The aim of this study was to assess the efficacy and safety of tumor necrosis factor (TNF)-α inhibition with infliximab (IFX) in treating recurrent and disabling chronic sciatica pain associated with post-operative peridural lumbar fibrosis. METHODS A double-blind, placebo-controlled

Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: possible implications for future pharmacologic treatment strategies of sciatica.

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METHODS The possibility to prevent nucleus pulposus-induced functional and structural nerve root injury by selective tumor necrosis factor-alpha inhibition was assessed in an experimental model in the pig spine. OBJECTIVE The objective of the study was to evaluate the role of tumor necrosis

Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study.

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METHODS Prospective randomized trial. OBJECTIVE To examine the effect of the tumor necrosis factor alpha (TNF-α) inhibitor, etanercept, on radicular pain by its epidural administration onto spinal nerves in patients with lumbar spinal stenosis. BACKGROUND TNF-α is thought to play a crucial role in

Tumor necrosis factor-alpha monoclonal antibody, infliximab, used to manage severe sciatica.

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METHODS An open-label study was conducted. OBJECTIVE To evaluate the efficacy and safety of infliximab, a monoclonal chimeric antibody, against tumor necrosis factor-alpha (TNFalpha) for the treatment of severe sciatica. BACKGROUND Evidence from animal studies indicates that TNFalpha plays a role in

A systematic review and meta-analysis of biological treatments targeting tumour necrosis factor α for sciatica.

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OBJECTIVE Systematic review comparing biological agents, targeting tumour necrosis factor α, for sciatica with placebo and alternative interventions. METHODS We searched 21 electronic databases and bibliographies of included studies. We included randomised controlled trials (RCTs), non-RCTs and

Clinical significance of tumor necrosis factor-α inhibitors in the treatment of sciatica: a systematic review and meta-analysis.

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OBJECTIVE Currently, no satisfactory treatment is available for sciatica caused by herniated discs and/or spinal stenosis. The objective of this study is to assess the value of tumor necrosis factor (TNF)-α inhibitors in the treatment of sciatica. METHODS Without language restrictions, we searched

[Efficacy of tumor necrosis factor-alpha blockade for severe sciatica?].

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The domain of sciatica is at the edge of a mini revolution. For ten years evidence have been accumulating in favour of a local inflammation rather than a pathology resulling only from a nerve compression. This hypothesis has first been strengthened by the discovery of inflammatory mediators in human

[Sciatica as a sign of hip disorder with a review of the diagnosis of aseptic necrosis of the femoral head].

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Comment on Williams NH, et al.: a systematic review and meta-analysis of biological treatments targeting tumour necrosis factor α for sciatica (Eur Spine J, 2013;22(9):1921-35).

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Can sciatica induced by disc herniation be treated with tumor necrosis factor alpha blockade?

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Answer to the Letter to the Editor of Gui-Tao Li et al. concerning: "A systematic review and meta-analysis of biological treatments targeting tumour necrosis factor α for sciatica" by Williams NH, Lewis R, Din NU, Matar HE, Fitzsimmons D, Phillips CJ, Sutton A, Burton K, Hendry M, Nafees S, Wilkinson C (2013) Eur Spine J; 22:1921-1935.

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Salvage operation for persistent low back pain and sciatica induced by percutaneous laser disc decompression performed at outside institution: correlation of magnetic resonance imaging and intraoperative and pathological findings.

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OBJECTIVE We identified several problems associated with percutaneous lumbar disc decompression (PLDD) based on a study of patients who required salvage operations for complications after undergoing PLDD at an outside institution. BACKGROUND PLDD has been performed as a new treatment for

Inflammatory biomarkers in patients with sciatica: a systematic review.

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This systematic review focusses on inflammation as an underlying pathogenic mechanism in sciatica. We addressed two questions in particular: (1) what inflammatory biomarkers have been identified in patients with sciatica in the literature so far? 2) is there an association between the

A Comparison of the Efficacy and Tolerability of the Treatments for Sciatica: A Network Meta-Analysis.

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BACKGROUND There remains a lack of a systematic summary of the efficacy and safety of various medicines for sciatica, and discrepancies among these exist. OBJECTIVE The aim of this study is to comprehensively assess the efficacy of and tolerance to several medical options for the treatment of

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