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Effects of secretin infusion on myocardial performance and metabolism in the dog.

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The effects of pharmacological doses of secretin were studied in closed-chest, pentobarbital anesthetized dogs. Infusion of secretin 16 clinical units (CU)/kg-h caused a rise in cardiac output (p less than 0.01), peak first derivative of the left ventricular pressure (p less than 0.01), and heart

Cardiac effects of secretin; an approach to its mechanisms of action as shown by beta-adrenergic blockade and measurement of left ventricular dimensions in dogs.

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In previous studies, the peptide secretin has demonstrated the ability to increase cardiac output and peripheral organ flow. In this investigation the mechanisms of the myocardial effects of secretin were studied. The secretin effects on cardiac output, stroke volume and systemic resistance were

Distribution of the increased cardiac output secondary to the vasodilating and inotropic effects of secretin.

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Infusion of the peptide secretin augments cardiac output due to vasodilating and inotropic properties. The aim of this investigation was to study how the increased cardiac output is distributed in the peripheral circulation. Before, during and after 15 min infusion of secretin 64 CU kg-1 h-1 flow

Passage of VIP/PACAP/secretin family across the blood-brain barrier: therapeutic effects.

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In recent years, VIP/PACAP/secretin family has special interest. Family members are vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), secretin, glucagon, glucagon like peptide-1 (GLP(1)), GLP(2), gastric inhibitory peptide (GIP), growth hormone

Cardiovascular effects of secretin infusion in man.

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Secretin infusion in man causes an increase in renal blood flow. The aim of the present study was to assess further the cardiovascular effects of the hormone. Secretin was infused at a rate of 2 CU/kg X h to patients with angina pectoris and normal left ventricular function. Cardiac output increased

Haemodynamic effects of pharmacological doses of secretin in patients with impaired left ventricular function.

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The haemodynamic effects of secretin 4 CU/kg.h was studied in seven patients with impaired left ventricular function. Cardiac output (P less than 0.01) and stroke volume (P less than 0.05) increased persistently during the infusion period, whereas the total systemic resistance fell (P less than

Class II G protein-coupled receptors and their ligands in neuronal function and protection.

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G protein-coupled receptors (GPCRs) play pivotal roles in regulating the function and plasticity of neuronal circuits in the nervous system. Among the myriad of GPCRs expressed in neural cells, class II GPCRs which couples predominantly to the Gs-adenylate cyclase-cAMP signaling pathway, have

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders.

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The pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor (PAC1R, ADCYAP1R1) is a member of the vasoactive intestinal peptide (VIP)/secretin/glucagon family of G protein-coupled receptors (GPCRs). PAC1R has been shown to play crucial roles in the central and peripheral

Transport of pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier and the prevention of ischemia-induced death of hippocampal neurons.

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PACAP is a member of the secretin/glucagon/VIP family of peptides and demonstrates neurotrophic and neuroprotective effects at very low concentrations. We have previously shown that PACAP crosses the BBB to a modest degree by way of a saturable transport system. PACAP is transported across the BBB

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