sennoside a/neoplasms

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Excretion and toxicity evaluation of 131I-Sennoside A as a necrosis-avid agent.

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1. Sennoside A (SA) is a newly identified necrosis-avid agent that shows capability for imaging diagnosis and tumor necrosis targeted radiotherapy. As a water-soluble compound, 131I-Sennoside A (131I-SA) might be excreted predominately through the kidneys with the possibility of nephrotoxicity. 2.

Identification of rhein as the metabolite responsible for toxicity of rhubarb anthraquinones

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Rhubarb is a popular food in Europe with laxative properties attributed to anthraquinones. Long term usage of rhubarb anthraquinones has been linked to colonic toxicity, including the formation of melanosis coli, which is associated with increased risk of colon cancer. The major purgative

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