sepsis/protease

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A Multi-Center Study Evaluating Clinical Course in Patients With COVID19 and Its Relationship to Cytokine Storm

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Study Rationale Over 100 patients were hospitalized at Hadassah in the recent 2 months with the diagnosis of COVID19. We would like to summarize the clinical outcomes and their correlation to a cytokine storm at Hadassah and additional hospitals and additional hospitals in Israel. COVID-19, the name

Intestinal Flora Research Plan for Critically Ill Patients

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With the improvement and development of medical technology and concepts, the types, progression, and outcomes of critically ill patients have changed dramatically. More and more critically ill patients can successfully escape from the early critical state, and the outbreak of multiple organ failure

Clinical Trial of the Use of Anakinra in Cytokine Storm Syndrome Secondary to Covid-19 (ANA-COVID-GEAS)

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This protocol has been prepared by the Systemic Autoimmune Diseases Group (GEAS) steering committee from the Spanish Society of Internal Medicine (SEMI) in response to the current urgent situation that are living in Spain because of the COVID-19 pandemic. The GEAS member are experts in the treatment

PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort

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INTRODUCTION 1.1 BACKGROUND Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is a new rapidly spreading infectious disease with no proven treatment options. The virus causes a spectrum of disease ranging from mild coryzal symptoms to severe respiratory compromise requiring

MicroRNAs in Renal Recovery - Pilot Study

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Acute kidney injury (AKI) occurs in almost 50% of patients treated in intensive care units. AKI mainly occurs after sepsis, acute ischemia, nephrotoxicity or hypoxia and leads to severe damage of the kidney and to an increased risk of mortality. The diagnosis of AKI is currently based on creatinine,

Therapeutic Plasmaexchange in Early Septic Shock

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Optimal Clinical Predictors to AKI in Cirrhotic Patients Experienced Acute Gastrointestinal Hemorrhage

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Specific aims of this study : 1. To examine the influences of acute gastrointestinal hemorrhage on the serological or urinary level of novel renal biomarkers in patients with cirrhosis. 2. To investigate the ability of novel biomarkers to predict the development of acute kidney injury and the

Assessment of Disease Severity, Progression and Treatment in Infected Patients Presenting to the Emergency Department

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Despite significant improvements in diagnostic and preventative measures, the incidence of sepsis has continued to escalate rapidly in hospitalized patients, with mortality rates ranging between 10 - 54%, depending on the level of severity. The earliest possible identification and assessment of

Predicting Pancreatic Necrosis Using mitDNA

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Acute pancreatitis (AP) is inflammation of the pancreas that can become a fatal disease or lead to severe complications . It is characterized clinically by abdominal pain and by increased pancreatic enzyme levels in the blood or urine. Gallstone migration and alcohol abuse are the two major risk

Acute Kidney Injury in Newborns With Perinatal Asphyxia

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Acute Kidney Injury is defined as the inability of the kidneys to excrete nitrogenous waste products and maintain fluid and electrolyte homeostasis. It is fairly common in newborn population and is a major contributor factor of neonatal mortality and morbidity. The most common form of Acute Kidney

Treatment of Severe Infection With Antihyperlipidemia Drug

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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection with a high mortality rate. The main causative agents in the ICU to cause sepsis and septic shock are gram negative bacteria Klebsiella spp., Escherichia coli (E. coli), and Pseudomonas aeruginosa (P.

Plasmaexchange in Early Septic Shock

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Catalytic Antibodies to Predict Uninvasively Late Transplant Failure

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Superantibodies are multifunctional antibodies combining the classical antigen-binding function with nonclassical biological activities, such as protease-like activity. In the past few years the role of proteolytic SuperAntibody (pSAb) has been evidenced in many biological processes in which their

Proadrenomedullin for Early Risk Assessment in the Emergency Department

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Emergency departments (ED) are becoming increasingly over-crowded, with patients facing prolonged waiting times. This is further aggravated by the shortage of available hospital space. Therefore, a safe and rapid triaging of patients is essential in improving the workflow within the ED, maximizing

Evaluation of the Effect of Gabexate Mesilate in the Hepatocyte Protection After Liver Resection

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