serum sickness/najas

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Development of a human scFv antibody targeting the lethal Iranian Cobra (Naja oxiana) snake venom.

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Snakebite is one of the health concerns worldwide. Naja oxiana is one of the venomous snakes with a high mortality rate. Anti-serum therapy is the only treatment of the victims. However, in some cases, antiserum injection leads to some side effects in host like serum sickness and anaphylactic shock.

Human monoclonal ScFv neutralize lethal Thai cobra, Naja kaouthia, neurotoxin.

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Animal derived anti-Naja. kaouthia (Thai cobra) venom is used for specific treatment of the snake bitten victims. Many recipients develop allergic reaction or anti-isotype response which causes serum sickness. A better therapeutic antibody is needed. In this study, long alpha-neurotoxin was purified

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