Inflammatory damage plays an important role in cerebral ischemic pathogenesis and represents a new target for treatment of stroke. Shikonin has gained attention for its prominent anti-inflammatory property, but up to now little is known about shikonin treatment in acute ischemic stroke. The aim of
Inspired by natural anti-inflammatory benzoxepanes, a series of new benzoxepane derivatives were designed and synthesized, and 10i emerged as the most effective compound in vitro with low toxicity. Further in vivo evaluation revealed that 10i could both ameliorate sickness behaviour through
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