simarouba amara/neoplasms

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Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines.

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The search for new anti-cancer drugs is one of the most prominent research areas of natural products. Numerous active compounds isolated from Brazilian Cerrado plant species have been studied with promising results. OBJECTIVE To investigate the cytotoxic potential of 412 extracts from Brazilian

Compounds from Simarouba berteroana which inhibit proliferation of NF1-defective cancer cells.

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A neurofibromatosis type 1 (NF1) based bioassay-guided phytochemical investigation on Simarouba berteroana led to the isolation of one new canthin-6-one-9-methoxy-5-O-β-D-glucopyranoside (1), seven known canthine alkaloids (2-8), two known quassinoids (9-10) and a known neo-lignan (11). The

Biological screening of select Puerto Rican plants for cytotoxic and antitumor activities.

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OBJECTIVE The objective of this study was to evaluate the cytotoxic and anticancer activities of extracts from 7-species of endemic and native plants from Puerto Rico. METHODS The plant species selected for this study were Canella winterana, Croton discolor, Goetzea elegans, Guaiacum officinale,

Anti-proliferative potential of phytochemical fractions isolated from Simarouba glauca DC leaf.

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Emerging advancements in anticancer drug discovery research are leaning towards the plant-based bioactive fractions, which is a cocktail of naturally abundant two or more substances with unique proportions, exhibiting greater potential to combat cancers than the individual molecules. Thus, isolation

Tricaproin Isolated From Simarouba glauca Inhibits the Growth of Human Colorectal Carcinoma Cell Lines by Targeting Class-1 Histone Deacetylases.

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While anticancer properties of Simarouba glauca (SG, commonly known as Paradise tree) are well documented in ancient literature, the underlying mechanisms leading to cancer cell death begin to emerge very recently. The leaves of SG have been used as potential source of anticancer agents in

Cytotoxic constituents of the twigs of Simarouba glauca collected from a plot in Southern Florida.

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Activity-guided fractionation of a chloroform-soluble extract of Simarouba glauca twigs collected from a plot in southern Florida, and monitored with a human epidermoid (KB) tumor cell line, afforded six canthin-6-one type alkaloid derivatives, canthin-6-one (1), 2-methoxycanthin-6-one (2),

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