skin neoplasms/nicotine

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Skin-tumour-promoting activity of processed bidi tobacco in hairless S/RV Cri-ba mice.

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Workers engaged in processing tobacco for the manufacture of bidis, the most popular smoking devices in India, are exposed to tobacco dust, volatile components and flakes via nasopharyngeal and cutaneous routes. In order to evaluate the risk of occupational tobacco exposure, the complete

Weak carcinogenic effect of masheri, a pyrolysed tobacco product, in mouse skin tumor models.

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Two commonly used varieties of masheri, pyrolysed tobacco products, were tested for their skin carcinogenicity in Swiss mice and the more sensitive strain of Swiss bare mice. In Swiss mice, painting of brown and black varieties of masheri extract did not show any tumorgenic effect; however, a

Youth indoor tanning and skin cancer prevention: lessons from tobacco control.

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Youth use of ultraviolet-emitting indoor tanning beds represents a present and emerging public health crisis. Nearly 30% of white female high school students report tanning indoors, and a quarter of high school tanners have used a tanning bed more than 20 times in the past year. Despite the

Implications of lessons learned from tobacco control for tanning bed reform.

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Tanning beds used according to the manufacturer's instructions expose the user to health risks, including melanoma and other skin cancers. Applying the MPOWER model (monitor, protect, offer alternatives, warn, enforce, and raise taxes), which has been used in tobacco control, to tanning bed reform

Tobacco habituated and non-habituated subjects exhibit different mutational spectrums in head and neck squamous cell carcinoma.

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin cancer in the world. Tobacco chewing is implicated with most of the cases of HNSCC but this type of cancer is increasing in non-tobacco chewers as well. This study was instigated to provide comprehensive variant and

Comparative carcinogenicity for mouse-skin of smoke condensates prepared from cigarettes made from the same tobacco cured by two processes.

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Bright tobacco grown in Mexico was either flue-cured and redried (FC) or air-cured and bulk-fermented (AC). Both FC and AC were made into cigarettes standardized for draw resistance. FC and AC cigarettes were smoked under similar conditions in a smoking machine (one 2-second 25 ml. puff per minute

Effect of glycerol on local and systemic carcinogenicity of topically applied tobacco condensate.

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When glycerol was added to tobacco smoke condensate in acetone solvent, the topical carcinogenicity and the ability to produce epithelial hyperplasia in mice was reduced. Two doses of condensate were applied, combined with 2 concentrations of added glycerol. Age-standardized results show that

Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies.

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DNA repair is a complicated biological process consisting of several distinct pathways that play a central role in maintaining genomic stability. Research on DNA repair and cancer risk is a vital, emerging field that recently has seen rapid advances facilitated by the completion of the Human Genome

Tobacco smoke condensate cutaneous carcinogenesis: changes in Langerhans' cells and tumour regression.

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Tobacco smoke condensate was painted on the skin of BALB/c mice. It increased the density and changed the morphology of Langerhans' cells (LC). LC number in epidermal sheets of treated mice was significantly higher (1793 LC/mm2) than in controls (946 LC/mm2) (P < 0.0001) and remained elevated for 35

Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis.

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Historically our knowledge about the direct carcinogenic activity of cigarette smoke and its constituents grew from painting experiments on the skin of mice to produce papillomas and carcinomas. The neutral fraction of cigarette smoke condensate had most of the carcinogenic activity in this test and

Skin and dermal appendages stem cells exposure to tobacco smoke.

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Stem cells are thought to persist throughout human life possessing enormous capacity for proliferation and differentiation. These cells and their microenvironment are potential targets for environmental pollutions, for example tobacco smoke. Tobacco smoke consists of thousands of substances which

TUMOR-PROMOTING ACTIVITY OF EXTRACTS OF UNBURNED TOBACCO.

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Both an aqueous Balpha(OH)(2) extract and an acetone-benzene extract of unburned cigarette tobacco produced skin tumors when painted on mice previously treated with 125 microg of7,12-dimethylbenz[a]anthracene. The extract from as little as 0.5 cigarette per day was effective. The data are of

Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers.

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Glutathione S-transferase GSTM1, GSTM3 and GSTT1 and cytochrome P450 CYP2D6, CYP1A1 and CYP2E1 loci are susceptibility candidates for cancers of the upper aerodigestive tract because putatively protective and risk genotypes have been identified from studies in other diseases associated with alcohol

Sun exposure habits and health risk-related behaviours among individuals with previous history of skin cancer.

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OBJECTIVE The aim of the present study was to investigate possible associations between UV exposure and other health risk behaviours in different social environments and in regard to previous history of skin cancer. METHODS In two closely-located, equally-sized cities in Sweden, representing

Predictors of reconstruction with Mohs removal of nonmelanoma skin cancers.

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OBJECTIVE To assess clinico-demographic characteristics available before Mohs removal of nonmelanoma skin cancers of the head and neck as predictors of the need for extensive reconstruction. METHODS Retrospective chart review. METHODS Variables examined were age, sex, race, marital status, past

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