The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.

Lee; Kyeong

Won; Mi Sun

Kim; Hwan Mook

Park; Song Kyu

Lee; Kiho

Lee; Ki Hoon

Lee; Chang Woo

Lee; Jung Joon

Chung; Kyung Sook

Kim; Bo Kyung

Jin; Yinglan

Lee; Seung-hee

Korea Research Institute of Bioscience and Biotechnology

Dongguk University Industry-Academic Cooperation Foundation

Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient

stomach neoplasms

hypoxia

stomach neoplasms/hypoxia

Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient

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