substance dependence/fatigue

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Medication development of ibogaine as a pharmacotherapy for drug dependence.

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The potential for deriving new psychotherapeutic medications from natural sources has led to renewal interest in rain forest plants as a source of lead compounds for the development of antiaddiction medications. Ibogaine is an indole alkaloid found in the roots of Tabernanthe iboga (Apocynaceae

[Pharmacological and psychosocial aspects of drug dependence].

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Use and abuse of psychotropic drugs start with history, but toxicomania starts much later, with the discovery of morphine, in early XIXth. Century; and increases sharply after the 2nd. World War. The author reviews the general classifications of drug abuse, stressing the many differences among them,

[Quality of life in patients before and after total hip arthroplasty].

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BACKGROUND Osteoarthritis is the most common joint disease in adults and according to WHO is one of the civilisation threats. Total joint replacement is the best method of treatment of severe osteoarthritis. METHODS The study group consisted of 62 (44 women, 18 men) patients, who due to the severe

Case ascertainment of alcohol dependence in general population surveys: 'gated' versus 'ungated' approaches.

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Social role impairment and other forms of maladaptation are referenced explicitly in the case definitions for the drug use disorders within DSM-IV-TR, but there is continuing debate about whether and how to include these manifestations of 'clinical significance' in diagnostic criteria and assessment

Computerized ambulatory monitoring in psychiatry: a multi-site collaborative study of acceptability, compliance, and reactivity.

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Computerized ambulatory monitoring overcomes a number of methodological and conceptual challenges to studying mental disorders, however concerns persist regarding the feasibility of this approach with severe psychiatric samples and the potential of intensive monitoring to influence data quality.

Assessing cannabis dependence in community surveys: methodological issues.

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Drug-related social role impairments and social maladaptation are referenced explicitly in the case definitions for drug dependence within DSM-IV-TR. Nonetheless, cases of drug dependence without this type of secondary consequence have been observed in recent epidemiological studies. When an

Long-term issues in the treatment of sleep disorders.

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Insomnia is a disorder characterized by chronic sleep disturbance associated with daytime disability or distress, such as memory impairment and fatigue, that occurs despite adequate opportunity for sleep. Insomnia may present as difficulty falling/staying asleep or as sleep that is nonrestorative.

[Bromazepam in the treatment of somatized psychogenic disorders (author's transl)].

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The clinical effects are reported of the benzodiazepine derivative, bromazepam (Lexotanil) in the treatment of psychosomatic disorders in the course of neurotic, psychovegetative, and masked depressive syndromes. The drug was administered orally in 301 patients (178 males, and 123 females). Target

Should caffeine abuse, dependence, or withdrawal be added to DSM-IV and ICD-10?

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OBJECTIVE The authors reviewed basic science and clinical data on caffeine abuse, dependence, and withdrawal in order to make a conclusion about whether these disorders exist and should be included in DSM-IV and ICD-10. METHODS Studies were located through computerized searches, reference sections

[Modafinil in psychiatric disorders: the promising state reconsidered].

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BACKGROUND For more than two decades psychiatrists have known about and have promoted modafinil, a very promising stimulant that boosts wakefulness in cases of narcolepsy and also enhances cognitive functions. At present, however, we must conclude that modafinil is hardly ever used to treat illness

[Prevention of psychosocial issues and drug addiction in workers employed in building great infrastructures: first outcomes of an experience in the Florence area].

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The research on stress, mobbing, and substance dependence in workers employed in the building of the great infrastructures is part of the project Euridice-Ten. The 75% of the workers employed took part in the research through an anonymous and structured questionnaire. The Clinica del Lavoro of the

Mental disorder in limb reconstruction: Prevalence, associations and impact on work disability.

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This cross-sectional survey aimed to assess the prevalence of depression, anxiety, post-traumatic stress disorder (PTSD), and drug and alcohol dependence in a limb reconstruction population and examine associations with demographic and functional variables. As part of routine clinical care, data

Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center.

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Males and females who use methamphetamine (MA) differ in sociodemographics, MA diagnoses, comorbidities, and brain activity. The objective of this study was to investigate sex differences in the characteristics of MA use and dependence in patients at a Thai substance treatment center. Demographic,

Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence.

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Methamphetamine (MA) is a potent agonist at the trace amine-associated receptor 1 (TAAR1). This study evaluated a common variant (CV) in the human TAAR1 gene, synonymous single nucleotide polymorphism (SNP) V288V, to determine the involvement of TAAR1 in MA

Outpatient Engagement Lowers Predicted Risk of Suicide Attempts in Fibromyalgia.

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OBJECTIVE Fibromyalgia (FM) patients are 10x more likely to die by suicide than the general population. The purpose of this study was to externally validate published models predicting suicidal ideation and attempts in FM and identify interpretable risk and protective factors for suicidality unique

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